The prevalence of chronic limb ischemia ranges from 3 up to 10%.
As the main cause of non-traumatic amputations,
peripheral artery disease (PAD) leads to a working age population decrease.
This is a serious social problem which causes the urgent need to improve the diagnostic approaches.
Nowadays there is a great need to develop the new methods for a sensitive and specific assessment of a skeletal muscle perfusion.
Dynamic contrast-enhanced magnetic resonance imaging (MRI) provides a...
Methods and Materials
A total of 25 PAD subjects with claudication symptoms and mean ankle-brachial index (ABI) 0.6±0.15 were studied.
Group characteristic presented at Table 1.
All performed supine plantar flexion exercise in a 1.5T MRI scanner until limiting symptoms with intravenous gadolinium-based contrast media administration (GdDPA,
“Magnevist”) before the medical treatment initiation and 6.9±2 months later. Peak tissue perfusion (TP),
time-to-peak TP and time-to-peak arterial input flow (AIF) were measured...
Mean ABI after 6 months follow up was 0.68±0.19 and didn’t differ significally from the initial (p=0.13).
All patients were divided in two groups due to ABI level.
Group 1 presented with ABI increase for 0,04 and more and consisted of 16 patients (70%).
Group 2 (n=9) showed ABI decrease or the same as initial. Group 1 showed no changes in MRI tissue perfusion measures (p>0.05) The data presented in table 2 (Figures 3-5). Initial Follow-up р Rest ABI 0.58±0.16 0.75±0.18 0.005 Exercise ABI...
Patients with ABI decrease showed significant deterioration in main perfusion characteristics - post-exercise skeletal muscle perfusion,
time-to-peak muscle perfusion and time-to-peak arterial input flow.
This illustrates that contrast-enhanced MRI is safe and effective method of skeletal muscle perfusion examination which may be useful in a PAD treatment evaluation.