ESCR 2016 / P-0040
Magna Cum Laude
Quantification of myocardial perfusion using dynamic CT perfusion analysis on third generation dual source CT in an ex-vivo porcine heart model
Congress: ESCR 2016
Poster No.: P-0040
Type: Scientific Poster
Keywords: Ischaemia / Infarction, Experimental investigations, Balloon occlusion, CT-Quantitative, CT, Cardiac, Animal (veterinary) studies
Authors: G. J. Pelgrim1, T. duguay2, M. Stijnen3, A. Varga-Szemes4, S. Van Tuijl3, U. J. Schoepf4, M. Oudkerk1, R. Vliegenthart1; 1Groningen/NL, 2Charleston/US, 3Eindhoven/NL, 4Charleston, SC/US


In an ex-vivo Langendorff porcine heart experiment, differences in CT-derived myocardial perfusion parameters between ischaemic and non-ischaemic segments can be detected at stenosis grades with an FFR<0.80. This model can be used in the systematic development and study of new imaging biomarkers for myocardial perfusion in a highly controllable and adjustable environment for CT. Additional research in a clinical setting is required to translate the findings of this study into suitable cut-off values for quantitative CT perfusion parameters in patients with CAD.

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