Purpose
Toestimate if magnetic resonance diffusion (MR) has a clinical role in assessment ofchronic liver disease.
Methods and Materials
Patient
28 subjects (M/F 20/8,
mean age 45,
age range 26-82) were evaluated,
from March to November 2010,
with abdominal MR-DwI:
7 healthy volunteers
7 subjects with chronic liver disease F0-F2 (METAVIR score)
7 F3-F4 Child A
7 F4 Child BC
classified as group I-II-III-IV,
respectively.
The inclusion criteria for the healthy subject for this study were as follows: absence and negative anamnesis for drug and alcohol abuse,
no current medication,
normal appearance of the liver on ultrasound study (no focal/diffuse liver disease),
negative anamnesis...
Results
I
II
III
IV
ADC150
ADC1000
D
f
2483 ± 290
1270 ± 91
1168 ± 108
0.18 ± 0.04
2296 ± 275
1229 ± 120
1120 ± 103
0.17 ± 0.04
2114 ± 268
1239 ± 84
1170 ±79
0.13 ± 0.05
1923 ± 153
1143 ± 55
1113 ± 80
0.12 ± 0.02
Table:results compared between groups.ADC and D as 10-6 mm2/s
A reduction in the mean value of f,
ADC150and to a lesser extent,
ADC1000is showed to progress from healthy volunteers (group...
Conclusion
Our results indicate that a stratification of patients with chronic liver disease for clinical use is not allowed by DwI.
However,
there is tendency for groups to reduce perfusion-related parameters to the progress of liver fibrogenic disease.
References
Colagrande S,
Pasquinelli F,
Mazzoni LN et al (2010) MR-diffusion weighted imaging of healthy liver parenchyma: repeatability and reproducibility of apparent diffusion coefficient measurement.
J Magn Reson Imaging 31:912-920
Pinzani M,
Rombouts K (2004) Liver fibrosis: from the bench to clinical targets.
Digestive and Liver Disease 36:231-242
Kanwal F,
Hoang T,
Kramer JR et al (2010) Increasing Prevalence of HCC and Cirrhosis in Patients with Chronic Hepatitis C Virus Infection.
Gastroenterology [Epub ahead of print]
Wong JB,
Bennet WG,
Koff RS at al(1998) Pretreatment evaluation...
Personal Information
Filippo Pasquinellia MD,
Giacomo Bellib MS,
Lorenzo Nicola Mazzonic MS,
Francesco Reginia,
Cosimo Nardia,and Stefano Colagrandea MD
a Department of Clinical Physiopathology,
Section of Radiodiagnostics,
University of Florence,
Azienda Ospedaliero-Universitaria.
Italy
b Section of Medical Physics,
Azienda Ospedaliero-Universitaria Careggi.
Italy
c CIRM,
University of Florence,
Azienda Ospedaliero-Universitaria Careggi.
Itlay