Purpose
It should be considered an accurate quantification of liver fat content using a 1.5T MRI in order to prevent the development of NASH(Non Alcoholic Steato Hepatitis).
T2*-corrected Dixon MRI can quantification of liver fat content in the presence of iron.
The aim of this study is to investigate three-point T2*-corrected Dixon magnetic resonance (MR) imaging for accurate quantification of fat content in the presence of iron and Gd-EOB-DTPA .
Back ground
Recently more and more people have been developing NASH (Non Alcoholic Steato Hepatitis).
10...
Methods and Materials
Phantoms
In order to simulate human fatty liver including lipid droplets in liver cells,
we used an emulsion method,
so that the mixture of agar gel emulsion is distributed uniformly fat micelles.
First,
sodium dodecyl sulfate 43mmol/L of emulsifier was dissolved in deionized water at room temperature.
Then using a magnetic hot plate 2%w/v of agar was dissolved into the solution.
30mL of this agar solution was injected into 50mL polypropylene containers (50mL jar Aiboi).
Then various amounts of iron,
canola oil and Gd-EOB-DTPA (Nihon...
Results
Real FFs and predicted FFs arequite similar( rspearman = 0.98)
Correlation between real fat and FFs containing SPIO(iron) was rsperman=0.73
Iron effects on fat quantification was corrected with T2* relaxation effects.
(rsperman=0.96)
Real FFs and Predicted FFs containing Gd-EOB-DTPA(0.2mmolGd/mL) are similar(rsperman= 0.95).
However,
Predicted FFs were a little underestimated.
Real FFs and Predicted FFs containing iron and Gd-EOB-DTPA are similar(rsperman= 0.97) with slightly variations of fat percentage.
Comperison of FFs fixed at 10%,
and predicted FFs,
containing iron and various concentration of Gd-EOB-DTPA are similar...
Conclusion
When doing the quantification of liver fat fractions there is a possibility of accurate quantification using correction for T2* relaxation effects of Gd-EOB-DTPA as has been proved for iron.
Also studying correction for T1 is required.
References
1) Assy N,
Kaita K,
Mymin D,
et al.
Fatty infiltration of liver in hyperlipidemic patients.
Dig Dis Sci 45(10):1929–1934,
2000.
2) Angulo P.
Nonalcoholic fatty liver disease.
N Engl J Med 346(16):1221–1231,
2002.
3) Motosugi U,
Ichikawa T,
Tominaga L,
et al.
Delay before the hepatocyte phase of Gd-EOB-DTPA-enhanced MR imaging: is it possible to shorten the examination time?Eur Radiol 19(11):2623-9,
2009.
4) Maas M,
van Kuijk C,
Stoker J,
et al.
Quantification of bone involvement in Gaucher disease: MR imaging bone marrow burden...
Personal Information
J.Matsumoto,
Y.
Okuyama,
M.
Shimada,
K.
Yoshikawa,
N.Akiba
Department of Radiological Sciences,
Faculty of Health Sciences,
Komazawa University
Komazawa1-23-1,
Setagaya-ku,
Tokyo,154-8525 Japan.
mail to:
[email protected]