Purpose
The true incidence of bone metastases is the subject of much debate,
and is not fully known.
The probability of bone metastasis originating from a primary site can be assessed only by knowing the prevalence of the primary tumour and its predilection for boneEvaluate the role of percutaneous ablation in the synergistic treatment with radiotherapy in the management of large bone metastasis.
Radiotherapy (RT) is the gold standard in bone metastasis treatment; it is dependent on oxygen for the action and for this reason may...
Methods and Materials
From may 2007,
31 oncologic patients who subsequently developed single painful bone metastases in absence of other visceral metastases.
All bone lesion were larger than 3 cm with a central poorly oxygenated and necrotic area.
Before undergoing ablation treatment,
patients were evaluated by means of a validated visual analogue scale (VAS) for pain assessment. Inclusion criteria were VAS from 4 to 10.
Exclusion criteria were the presence of other visceral or not-visceral metastasized site.
The role of ablation is to burn the necrotic center,
which...
Results
Patients had pain relief for a period ranging from 2 to 24 months (mean 7.8 mos).Technical success was 100%.
No major complicance occured.
The mean VAS after percutaneous ablation-RT treatment improved overall by 80% from 8.4 to 1.9 (mean 2.7).
Conclusion
In some measure,
our study suffers from considerable limitations such as the relatively low number of patients,
the imbalance between the two groups in terms of locations and size of the treated metastases and the retrospective design.
The generalisation and the applicability of our results to the general population with osteolytic bone metastases must be demonstrated.
These data suggest that the association of ablation procedure and radiotherapy treatment improves pain relief due to bone metastases.
Combined treatment using Ct guided ablation followed by RT is...
References
1.
Chow E,
et Al: Palliative radiotherapy trials for bone metastases: a systematic review.
JClinOncol,
2007
2.
Dupuy DE,
et Al: Percutaneous radiofrequency ablation of painful osseous metastases: a multicenter American College of Radiology Imaging Network trial.Cancer,
2009