Purpose
Renal cell carcinoma (RCC) represents the commonest primary malignancy of the kidney,
accounting for about 2% of adult malignancies [1,2].
The American Cancer Society estimates that in 2012 there will be 64,770 new cases of renal cancer,
including 92% RCCs,
with an estimated 13,570 deaths due to this disease [3].
With the wide-spread use of cross-sectional imaging studies as many as half of RCCs are found incidentally,
usually diagnosed at an early stage.
This may allow a more limited surgical resection of the neoplasms,
such...
Methods and Materials
Study Patients :
The records of 47 patients (30 men and 17 women) with 48 histologically proven RCCs were retrospectively analyzed.
One patient presented with two synchronous RCCs in the same kidney.
The mean age of patient population was 60 years,
with a range of 31-84 years.
The mean interval between CT examinations and surgery was less than two weeks.
Radical nephrectomy was performed in all cases.
Approval of this retrospective study was obtained from our institutional review board.
This study was complied with the...
Results
The histologic subtypes of RCCs included clear cell RCC (n=33),
papillary RCC (n=2),
chromophobe RCC (n=5),
mixed RCC (clear cell and chromophobe,
n=1),
collecting duct carcinoma (n=1),
unclassified RCC (n=2),
multicystic RCC (n=3) and clear cell RCC,
with sarcomatoid differentiation (n=1).
Tumor grading included grade I in 3 (6%) tumors,
grade II in 26 (55%) tumors,
grade III in 15 (31%) tumors and grade IV in four (8 %) neoplasms.
Pathologic analysis revealed stage T1a in 17 (36%) tumors,
stage T1b in 13 (27%) tumors,...
Conclusion
Accurate preoperative staging of RCC is important,
permitting optimal patient management [1,2].
The T component of the TMN staging classification system is a major factor in predicting prognosis and survival in these patients.
Local staging and differentiation between T1/T2 and T3a stages is significant in determining best surgical approach (conservative versus radical nephrectomy and laparoscopic versus open incision) [1,2].
Detection of perinephric fat invasion in RCC represents one of the commonest staging errors at CT examination [1,2,15,16].
Johnson et al in a retrospective study of...
References
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Horton KM,
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Current concepts in the diagnosis and management of renal cell carcinoma: role of multidetector CT and three-dimensional CT.
Radiographics 2001; 21:S237-S254.
Catalano C,
Fraioli F,
Laghi A,
et al.
High-resolution multidetector CT in the preoperative evaluation of patients with renal cell carcinoma.
AJR 2003; 180:1271-1277.
American Cancer Society.
Cancer Facts & Figures 2012.
www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-031941.pdf.
Eggener S.
TMN staging for renal cell carcinoma: time for a new method.
Eur Urol 2010; 58:517-521.
Jung SJ,
Ro JY,
Truong LD,...
Personal Information
Athina C.
Tsili1, Anna C.
Goussia2,
Alexandra Ntorkou1,
Aikaterini Ntoulia1,
Dimitrios Giannakis3,
Loukas Astrakas4,
Nikolaos Sofikitis3,
Vasiliki Malamou-Mitsi2,
Maria I.
Argyropoulou1
1Department of Clinical Radiology
2Department of Pathology
3Department of Urology
2Department of Medical Physics
University Hospital of Ioannina,
Greece.