Background There is a need for non-invasive method for hepatic steatosis assessment―eg, diagnosis of nonalcoholic fatty liver disease and steatohepatitis; and liver donor selection. The current gold standard techniques for evaluation of hepatic fat is MR spectroscopy (MRS) which separate fat and water resonances and subsequently provide an accurate fat fraction measurement(1). Unenhanced conventional CT provides high performance in qualitative diagnosis of macrovesicular steatosis > 30% ―Not clinically acceptable(2). Iron content affects fat quantification in both MRI(3) and CT(4). Here we developed an algorithm for...

Phantom Design (Fig. 1 and Table 1) The liver phantoms consisted of pig liver homogenized with five different fat contents and with three different iron contents. For each, saccharated iron oxide (SIO, 20mgFe/ml) was diluted with distilled water to obtain concentrations of 0, 40 and 80 mg of iron per 100 mg of solution. Fat volume fraction of each was calculated from result of the Soxhlet extraction (g/100g) and specific gravity (g/ml) of fat each phantom.Iron concentration in the liver phantoms were determined using the...

(Table 2) There were significant correlations between HUSECT and FVFtrue, and FVFDECT and FVFtrue on both the phantom size of 20cm and 30cm. FVFMRS was also significantly correlated with FVFtrue. DECT vs SECT (Table 2 and 3) The differences in the linear regression slope by phantom size were examined in each group devided by data acquisition (HUSECT or FVFDECT) and by iron content (Iron 0, 1+ and 2+). ANCOVA showed no significant difference between the two regression lines in any group, though the angle between...

FVFDECT may be more insusceptible to beam hardening effect due to phantom size than HUSECT, and provides a solution for noninvasive quantification of liver fat as well as MRS.

1. Bernard CP, Liney GP, Manton DJ, Turnbull LW, Langton CM. Comparison of fat quantification methods: a phantom study at 3.0T. J Magn Reson Imaging. 2008;27(1):192-7. 2. Park SH, Kim PN, Kim KW, et al. Macrovesicular hepatic steatosis in living liver donors: use of CT for quantitative and qualitative assessment. Radiology. 2006;239(1):105-12. 3. Hines CD, Agni R, Roen C, et al. Validation of MRI biomarkers of hepatic steatosis in the presence of iron overload in the ob/ob mouse. J Magn Reson Imaging. 2012;35(4):844-51. 4. Limanond...

Tomoko Hyodo, MD　 ([email protected]) Masahiro Okada,MD, PhD Kazunari Ishii, MD, PhD Takamichi Murakami, MD, PhD The Department of Radiology, Kinki University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511, Japan Masayuki Kudo, PhD,RT Tetsuya Wakayama, RT GE Healthcare Japan 　Hino,Tokyo 191-8503, Japan Peter Lamb, MS GE Global Research, One Research Circle, Niskayuna, NY 12309, USA Paulo R.S. Mendonça, PhD GE Global Research, One Research Circle, Niskayuna, NY 12309, USA Teruhito Mochizuki, MD The Department of Diagnostic and Therapeutic Radiology, Ehime University Graduate School of Medicine,...