Lymphoma newly diagnosis: comparison between whole body MRI-DWIBS and 18FDG PET/CT.

Congress:

ECR 2013

Poster Number:

C-1937

Type:

Scientific Exhibit

Keywords:

Multidisciplinary cancer care, Lymphoma, Haematologic diseases, Staging, Imaging sequences, Comparative studies, PET-CT, MR-Diffusion/Perfusion, MR, Oncology, Lymph nodes, Haematologic

Authors:

M. Ficco¹, N. Maggialetti², C. Ferrari³, C. Minoia¹, F. IUELE³, C. Buquicchio⁴, A. Guarini¹, C. M. Florio¹, G. Rubini³; ¹Bari/IT, ²Molfetta/IT, ³Bari (BA)/IT, ⁴Trani/IT

DOI:

10.1594/ecr2013/C-1937

DOI-Link:

https://dx.doi.org/10.1594/ecr2013/C-1937

Fig. 1

Fig. 4: Database with nodal involvement and extranodal localizations for each patient

Fig. 5: Statistical evaluation with K value.

Fig. 7: Volumetric Whole Body-DWIBS post-processing of the same patient, confirms MR...

$Fig. 8: The 18FDG-PET\CT of the same patient confirms the massive and diffuse nodal involvement. References: Nuclear Medicine Unit – Department of Interdisciplinary Medicin., University of Bari$

Fig. 8: The 18FDG-PET\CT of the same patient confirms the massive and diffuse nodal...

Purpose

The aim of this prospective study was to assess the role of whole-body MRI/DWIBS in the staging of new diagnosed lymphoma compared to 18F-FDG-PET/CT, actually considered gold-standard technique.

Methods and Materials

We enrolled twenty-five consecutive patients with new diagnosed lymphoma histologically confirmed (see the table for the sample’s features). All of them underwent whole-body MRI (coronal T1-weighted, coronal STIR and axial DWIBS sequences) and performed 18F-FDG-PET/CT, within 2 weeks before/later whole-body MRI. Axial DWIBS sequencesincluded three acquisitions of b factor (0, 500 , 1000). The total acquisition time for Whole Body-MRI/DWIBSwas approximately 25 minutes. Whole Body-MRI/DWIBS was independently evaluated by two blinded observers andlymph nodes largerthan 10 mmin short-axis diameter, inthe coronal plane on T1-weighted and...

Results

18F-FDG-PET/CT showed 75 nodal stations involved and detected 10 extranodal lesions. WB-MRI/DWIBS showed 80 nodal stationsinvolved and detected 12 extranodal lesions, revealing an overstaging in 2/25 (8%) patients and an understaging in 1/25 (4%). A statistical evaluation with the Cohen k was performed to assess the degree of correlation between the two methods, for each nodal stations and extranodal sites (see data in the table). In 10 \ 25 patients we found differences in the attribution of disease in each of the stations described. Of...

Conclusion

Our initial results show that agreement between whole-body MRI-DWI and18F-FDG-PET/CT in lymphoma staging, is moderate to good. Although18F-FDG-PET/CT remains the gold standard for lymphoma staging, WB-MRI/DWIBS may be considered an emergingfunctional whole-body imaging modality that may eventually give complementary informations.

References

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