Cardiac Magnetic Resonance (CMR) is the gold standard for ventricular function analysis.
there are no studies in the available literature on the evaluation of atrial function role in the diastole assessed by CMR.
The aim of this study is to compare the atrial and ventricular dV/dT curves and derived diastolic parameters in HCM patients versus HC.
Methods and Materials
23 patients (16 men; age 42 + 14) with known HCM and 42 HC (19 men; age 41 + 17) were enrolled in this prospective and multicentric study (University Hospital “P.
Giaccone” – Palermo; “G.
National Council of Research - Pisa).
Atrial and ventricular function was studied through cine SSFP (Steady State Free Precession) MRI sequences on Short Axis (SA) view including the left ventricle and all of the left atrium.
Image analysis was performed using the software Tracking...
HCM patients had a ventricular Peak Filling Rate E (PFR E) of 365 + 110 ml/s,
as compared to the PFR E of 423 + 129 ml/s in HC (P=0.07).
Not significant differences have been observed in ventricular PFR A (210 + 107 ml/s vs 219 + 107 ml/s; NS) and Deceleration Time (DT) (159 + 60 ms vs 149 + 40 ms; NS) (Table 1). Atrial passive Peak Emptyng Rate (PER E) was significantly reduced in HCM patients as compared to HC (average -146 + 53 ml/s vs -227 + 86 ml/s; P<0.0001 ),
whereas the atrial active...
MRI is useful in the combined assessment of atrial and ventricular diastolic function.
HCM patients showed impaired atrial function when compared to HC.
It’s thus a logical to assume that early atrial involvement occurs in HCM diastolic dysfunction.
1) Braunwald E.
Malattie del cuore – Trattato di medicina cardiovascolare.
Casa Editrice: Elsevier Masson 2007. 2) Maceira et al.
Reference left atrial dimensions and volumes by steady state free precession cardiovascular magnetic resonance.
Journal of Cardiovascular Magnetic Resonance 2010. 3) Maceira et al.
Normalized Left Ventricular Systolic and Diastolic Function by Steady State Free Precession Cardiovascular Magnetic Resonance Journal of Cardiovascular Magnetic...