MR Spectroscopy is a help for MRConventional Imaging in the identification of bone and soft tissue lesions. Choline is a precursor for Acetylcholine and the membrane constituent Phosphatidylcholine: an increase of the choline peak means an increase in the cellular membrane activity and proliferation. The first goal of this trial was to identify a 1H-MR spectroscopy protocol for the study of bone and soft tissue lesions. Then we should evaluate the contribution of 1H-MR spectroscopy to the differential diagnosis of MSK lesions, analyzing their choline...

Between June 2011 and December 2012 we performed MR-spectroscopy sequences in 147 patients (90M, 57 F) with bone and soft tissue lesions. Our protocol was based on single-voxel point-resolved spectroscopy sequence. To identify the optimal parameters combination we used several parameters sets including: TR, TE=35,144,288; NEX and coils. The volume of interest within lesions was positioned on the areas of early enhancement according to the findings of dynamic contrast-enhanced MR imaging. (Fig.1-4) Several methods have evolved for analysis of MR Spectroscopy results. These methods include...

Choline was qualitatively detected in many patients with malignant tumors (fig. 5-15) and in some patients with benign lesion (myositis, bone cortical defect, lipoma, area of hyperplastic synovial membrane). (fig.16-23) Inparticular, the choline peak may be detected in benign lesions characterized by high cellularity, vascularity, inflammatory cells. The TE value that assured more repetitive results was 144 ms. The minimum lesion dimension for a clinical acceptable scan time was 1.5x1.5x1.5 cm2.

Most MR Spectroscopy studies of musculoskeletal tumors have been focused on increased levels of choline in malignant bone and soft-tissue tumors; cholineis a useful marker of malignancy in several organ systems, for example brain, breast and prostate. For soft tissues, the biologic basis of these observations showing that disorders that influence cell membrane turnover result in changes in the concentration of choline-containing compounds. These compounds are detectable with MR Spectroscopy as a choline peak at 3.2 ppm In our trial, the qualitative results analysis confirmed...

Chien-Kuo Wang, MD, Chun-Wei Li, PhD, Tsyh-Jyi Hsieh, MD, Sang-Hsiung Chien, MD, Gin-Chung Liu, MD, Kun-Bow Tsai, MD. Characterization of Bone and Soft-Tissue Tumors with in Vivo 1H MR Spectroscopy: Initial Results.Radiology 2004; 232:599–605 Fayad LM, Wang X, Salibi N, Barker PB, Jacobs MA, Machado AJ, Weber KL, Bluemke DA. Feasibility Study of Quantitative Molecular Characterization of Musculoskeletal Lesions by Proton MR Spectroscopy at 3 T. AJR 2010; 195:W69–W75 QI Zi-hua Q,Chuan-fu L,Zhen-feng L, Kai Z, Qian W, De-xin Y. Preliminary study of 3T 1H...

M. Stratta1, T. Robba1, G. Regis1, V. Clementi2, C. Faletti1; 1Turin/IT, 2Bologna/IT 1Dipartimento di Diagnostica per Immagini, AO Città della Salute e della Scienza di Torino, Presidio Ospedaliero CTO [email protected] [email protected] Via Zuretti 29, 10100 Torino (Italy) tel. 011-6933728 2GE Healthcare