Aims and objectives
Introduction Conventional ultrasound is being used widely for screening patients who are at high risk of hepatocellular carcinoma (HCC) [Chalasani N 1999].
Elastography is a stiffness imaging modality [Ophir J 2000] which is based on the premise that tissue elasticity can be changed by pathological conditions such as neoplasm or inflammation [Yeh WC 2002].
An excitation force is applied and the tissue response is measured to infer the mechanical properties of the tissue. Supersonic shear wave...
Methods and materials
This was a prospective study approved by the local research ethics committee,
University of Malaya,
and informed consent was obtained from all patients.
Patients referred to the Department of Biomedical Imaging,
University Malaya Medical Centre,
Malaysia for multi-phase computed tomography (CT) liver examinations from July 2012 to March 2013 were screened. The patients were then divided into the following groups based on the CT findings: newly diagnosed hepatocellular carcinoma (HCC),
Results 41 patients (30 male,
aged 59.7 ± 12.5 years) completed the SWE examination.
Patients are categorised to HCC,
liver metastasis and control groups (Refer Fig.
2). 17 patients (29.3%) of patients did not complete the SWE examination (Refer Fig.
3). Table 1 and 2 show the mean and maximum elasticity values for HCC,
metastasis and control group.
4 shows the box plot for comparison of the elasticity values. There were significant differences (p<0.05) in tissue elasticity...
SWE is a non-invasive,
quantitative and non-radiating method which provides additional information to characterise HCC and metastatic liver nodules based on the tissue elasticity values.
Further studies with larger patient population should be performed to determine its diagnostic role in assessing focal liver lesions including other malignant and benign liver lesions.
Kah Lai Choong,
MBBS firstname.lastname@example.org Department of Biomedical Imaging Basri JJ Abdullah,
MBBS email@example.com Department of Biomedical Imaging Gnana Kumar,
MBBS firstname.lastname@example.org Department of Biomedical Imaging Chai Hong Yeong,
BSc email@example.com Department of Biomedical Imaging Khean Lee Goh,
MBBS firstname.lastname@example.org Department of Internal Medicine Boon Koon Yoong,
MBBS email@example.com Department of Medicine Faculty of Medicine,
Breast lesions: quantitative elastography with supersonic shear imaging - preliminary results.
Radiology 2010; 256 (1): 297-303.Bavu E,
Noninvasive in vivo liver fibrosis evaluation using supersonic shear imaging: a clinical study on 113 hepatitis C virus patients.
Ultrasound in Med.
2011; 37 (9): 1361-1373. Bercoff J,
Supersonic shear imaging: a new technique for soft tissue elasticity...