Aims and objectives
The aim of this study was to investigate the efficacy and survival of transarterial chemoembolization (TACE),
radiofrequency ablation (RFA) and combined therapy,
and comparing the three modalities on matched patients groups.
Methods and materials
Sixty patients with HCC on top of liver cirrhosis (40 males & 20 females),
their mean age 49 years (range 45 – 70 years),
were included in this 3 arms study.
The study was conducted between (August 2011 to February 2013) in the Upper Egypt cancer institute and Assiut University Hospital.
The protocol of the study has been approved by the ethical committee of research of Faculty of Medicine,
Assiut University,
and informed consent of the patients has been taken before the study.
Patients were...
Results
I- Group 1: (TACE):
This group included 20 patients for whom TACE was done.
Twelve patients showed good response (good lipidol uptake with no enhancing residual tumor tissue in triphasic CT).
Eight patients showed poor response (residual enhancing tumor tissue) for whom another procedure was done one month later.
Two out of the 8 patients showed good response.
So,
collectively 14/20 patients (70%) showed good response and 6/20 patients (30%) showed poor response (table 1).
AFP in patients who showed good response (14/20) is reduced...
Conclusion
DISCUSSION:-
HCC is the third most important cause of cancer related mortality worldwide [10].
Locoregional treatment options such as TACE and RFA are minimally invasive treatment options that may individually or in combination address the pertinent issue of successful tumor targeting and preservation of liver function [10].
The current study is three arms one,
planned to compare TACE,
RFA and combined therapy with matched patients groups.
One year follow up of all patients could be achieved hardly and with great effort.
Reporting the response; the...
References
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