Learning objectives
To highlight the important imaging and histological features of lymphoma.
To exhibit different imaging findings of lymphoma at several anatomic locations.
To illustrate nodal and extranodal manifestations of lymphoma.
To demonstrate the role of different imaging modalities in the diagnosis,
staging and evaluation of treatment of lymphoma.
Background
Lymphoma is a term referring to a number of neoplasms of lymphocyte precursors or mature lymphocytes (T,
B or natural killer cells),
that predominantly involve tissues other than the bone marrow,
rather than the bone marrow and blood.
Lymphoma is the most common primary haematopoietic malignancy.
More than 60 entities have been described in the 4th edition of the World Health Organisation Classification of Tumours of Haematopoietic and Lymphoid tissues.
The neoplasms are classified according to the morphology,
genotype and immunophenotype of the originating cell...
Findings and procedure details
In this section,
the commonest types of lymphoma will be discussed in further detail accompanied by relevant images.
Hodgkin’s lymphoma(HL) is characterised by the presence of Reed-Sternberg cells and their variants accompanied by an inflammatory background composed mainly of lymphocytes,
eosinophils and fibroblasts.
Mediastinal lymphadenopathy is the commonest presentation of HL with anterior and middle mediastinal lymph node involvement followed by retroperitoneal nodes [1].
Occasionally,
hilar lymphadenopathy may be present accompanied by lung involvement.
However,
studies show that the lungs are never involved in the...
Conclusion
Current advances in the medical imaging field and availability of increasingly sensitive diagnostic methods has greatly advanced our ability to accurately diagnose,
stage and follow up patients with malignant lymphoma.
Computed tomography,
magnetic resonance and positron emission tomography have significantly assisted in the correct identification of lymphoma and have augmented or replaced less sensitive or less practical modalities such as plain radiography and lymphangiography.
This poster has reviewed a number of common and less common presentations of lymphoma,
so as to better diagnose and differentiate...
Personal information
V Attard,Specialist Trainee
Department of Pathology,
Histopathology Section
Mater Dei Hospital,
Malta
[email protected]
A Giotas,Specialist Trainee
Department of Haematology
Mater Dei Hospital,
Malta
J Muscat,
Medical Imaging Department,
Mater Dei Hospital,
Malta currently a Clinical Fellow in Breast and Paediatric Imaging at BSUH NHS,
UK.
We thank Dr.
David James Camilleri,
Consultant Haematologist in the Department of Haematology,
Mater Dei Hospital,
Malta for his kind input and guidance on the compilation of this poster.
References
Swerdlow SH,
Campo E,
Harris NL,
et al.
(Eds).
World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues,
IARC Press,
Lyon 2008.
North LB,
Libshitz HI,
Lorigan JG.
Thoracic lymphoma.
Radiol Clin North Am 1990; 28:745.
Møller MB,
Pedersen NT,
Christensen BE.
Diffuse large B-cell lymphoma: clinical implications of extranodal versus nodal presentation--a population-based study of 1575 cases.
Br J Haematol 2004; 124:151.
Armitage JO,
Weisenburger DD.
New approach to classifying non-Hodgkin's lymphomas: clinical features of the major histologic subtypes.
Non-Hodgkin's Lymphoma Classification...
