Aims and objectives
Maximum standardized uptake value (SUVmax) is a commonly used as a semiquantitative parameter in PET/CT studies valuable for diagnosis of various diseases and therapy response.
However,
It is reported that SUVmax is modified by various factors,
differs from the true value,
then it makes undervalue or overvalue patient conditions.
We have experienced that SUVmax is occasionally not usefulto diagnose and compare with other patients in clinical.
It was known that patient’s physique make it be difficult to get true SUVmax,
and it is reported to...
Methods and materials
Subjects
Object were consecutive 135 patients underwent 18F-FDG-PET/CT examination for routine clinical purpose,
who agreed to research,
in August 2013 to March 2014.
The 18F-FDG-PET/CT study has been performed for malignant discrimination; 11pts.,
for staging malignant disease; 47pts.,
for decision of treatment result; 5pts.,
for follow-up; 65pts.,
health screening; 3pts.
Four patients whose blood glucose is over 150 mg/dl and/or who had multiple liver tumors were excluded.
In the all patients,
after over 6 hr fasting,
each patient was injected with approximately 185MBq of fluorine-18...
Results
Result
In the aortic and liver ROIs,
SUVmax (mean±SE) were 2.04±0.29 and 2.50±0.28 in the low BMI group,
2.41±0.41 and 2.98±0.47 in the normal BMI group,
and 2.71±0.28 and 3.42±0.41 in high BMI group,
respectively.
SULPE were 1.72±0.27 and 2.10±0.27 in the low BMI group,
1.90±0.35 and 2.36±0.44 in the normal BMI group,
and 1.86±0.27 and 2.33±0.35 in the high BMI group,
respectively.
SUVS were 1.70±0.27 and 2.07±0.28 in the low BMI group,
1.82±0.30 and 2.25±0.36 in the normal BMI group,
and 1.76±0.26 and 2.23±0.35...
Conclusion
SUVmax was found to be dependent on patient weight with a systematic variation of about 30% across the three categories: underweight,
normal,
and overweight.
SULPE should be considered as a clinical useful proxy measure of FDG uptake.
Personal information
Department of Radiology,
Kansai Medical University,
Hirakata,
Osaka,
Japan.
Author: Yumiko Kono,
Kansai Medical University,
2-5-1,Shinmachi,
Hirakata,
Osaka,
573-1010,
Japan.Phone: 81-72-804-0101;Fax: 81-72-804-2072; E-mail:
[email protected]
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