Aims and objectives
Liver is one of the common sites of haematogenous metastases of most of the primary malignancies in the body.
Gastrointestinal,
breast,
melanoma,
neuroendocrinal and lung cancers are the most common primary cancers responsible for metastatic liver involvement [1,2].
The differentiation between malignant and benign focal liver lesions always remains a diagnostic challenge for aradiologist.
For detection and characterisation of focal liver lesions,
various imaging modalities are being used,
including US,
multi-phase contrast enhanced CT,
CT portography,
MRI and perfusion studies using dedicated contrast media.
Of...
Methods and materials
Patients:
This was a prospective study doneon 80 lesions in 59 patients over a period of 6months duringSeptember2013 to March2014.
These patients were referred for MRI of abdomen in the Department of Radiology of our hospital from different oncology units.
Only those lesions,which underwent FNAC or biopsy under US or CT guidance or had excision done during the abdominal surgery or had typical imaging features on MR or other imaging modalities,
were included in the study.
Atypical lesions were correlated with pathologicaldiagnosis.
Informed consent was...
Results
Patients:
A total of 80 focal liver lesions in 59 patients fulfilled the inclusion criteria.
Mean age of these patients was 53 years (range,
4-83 years) with 37 male (63%) and 22 female ( 37%).
Liver lesions:
There were 40 benign and 40 malignant lesions which included 9 hepatocellular carcinoma (11.25%),
30 metastases (37.5%),
1 hepatoblastoma (1.25%),
19 hemangiomas (23.75%),
14 hepatic cysts (17.5%),
2 adenomas (2.5%),
2 FNH (2.5%) and 3 regenerating or degenerating hepatic nodules (3.75%).
Qualitative assessment on DW imaging:
Allcystic lesions...
Conclusion
Diffusion-weightedimaging is a fastMR based sequence (single-shot EPI) which adds only 3 to 4 minutes to the entire examination and has proven very useful for the detection,
further characterization and subsequent differentiation between benign and malignant lesions without the administration of contrast media,
by quantifying diffusion effects via ADCs measurement.
This is even more useful in the setting when post Gadolinium-images can not be obtained due to poor renal function or history of allergy.
Since solid benign lesions are more difficult to differentiate from malignant...
Personal information
Dr.
Rashmi Sudhir
Consultant Radiologist
Basvatarkam Indo-American Cancer Institute & Research Center
Hyd,
India.
References
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Bruegel M et al.(2008) Characterization of focal liver lesions by ADC measurements using respiratory gated diffesion...