Intracystic Papillary Carcinoma of the Breast: Clinical and Radiological Findings with Histopathologic Correlation

This poster is published under an open license. Please read the disclaimer for further details.

Congress:

ECR 2015

Poster Number:

C-2078

Type:

Scientific Exhibit

Keywords:

Staging, Diagnostic procedure, Biopsy, Ultrasound, MR, Mammography, Oncology, Breast, Cancer

Authors:

S. S. AlSharif¹, J. Lian², X. Tan², S. Sun², R. Hsu², A. Omeroglu², B. Mesurolle²; ¹Jeddah/SA, ²Montreal, QC/CA

DOI:

10.1594/ecr2015/C-2078

DOI-Link:

https://dx.doi.org/10.1594/ecr2015/C-2078

Fig. 2: Oval indistinct mass

Fig. 3: Irregular spiculated mass

Fig. 4: clustered coarse heterogeneous microcalcifications associated with a mostly...

Fig. 1: H&E at 100x magnifications, showing the fibrotic capsule on top and papillary...

Aims and objectives

To describe the imaging features of intracystic papillary carcinoma (ICPC) of the breast and correlate it with histopathological findings Describe imaging features of cases associated with invasive ductal carcinoma (IDC) To emphasize on the importance of early detection as it impact subsequent management

Methods and materials

Retrospective review of the pathology database in women who underwent surgery for breast cancer with the diagnosis of pure and mixed ICPC from January 2006 – March 2014 Total of 30 patients identified with 35 lesions (20 pure and 15 mixed) Images were reviewed by two radiologists in consensus following the BI-RADS Lexicon Descriptive statistical analysis (chi squared) was performed to identify statistically significant (p=0.05) imaging features of ICPC, and whether they could help distinguish between pure and mixed lesions, and correlate them to the...

Results

Patients mean age was 68.6 years (+/-12.2 years) 13/35 (37%) lesions that were palpable clinically 7/30 patients (23%) presented with bloody nipple discharge slight left side predominance with R : L ratio of 14:21 Out of 2751 biopsies obtained for breast cancer, 35 lesions (1,3%) with IPC were detected in 30 patients. Of these, 15 lesions (43%) were associated with IDC and 20 lesions (57%) we not associated with IDC. Mean lesion size 1.8 +/-0.9cm (1cm to 3cm) All lesions were showing localized disease Mammographically,...

Conclusion

Imagingconcurs with literature but is not distinguishing for pathology Surgical excision is critical for diagnosis

Personal information

Authors Contact Info: Shaza AlSharif: [email protected] Benoit Mesurolle: [email protected]

References

Dogan BE, Whitman GJ, Middleton LPet-al. Intracystic papillary carcinoma of the breast.Am JRoentgenol. 2003;181 (1): 186. Khoury T, Hu Q, Liu Set al.Intracystic papillary carcinoma ofbreast: interrelationshipwithin situandinvasive carcinomaand a proposal ofpathogenesis.ModernPathology2014;27: 194-203. Lam WW, Chu WC, Tang APet al. Role of radiologic features in the management of papillary lesions of the breast.Am JRoentgenol 2006;186(5):1322-7. Lam WW, Tang AP,Tse G et-al. Radiology-Pathology conference: papillary carcinoma of the breast.Clin Imaging2005;29 (6): 396-400. Liberman L, Feng TL,Susnik B. Case 35:intracystic papillary carcinoma with invasion.Radiology 2001;219 (3): 781-4....