DW-MRI has the potential to provide a standardized imaging measurement in therapeutic responseevaluation.
We investigate the possibility of DWI as an imaging bio marker and evaluate its ability to measure tumorresponse in carcinoma cervix. Aims: To measure the apparent diffusion coefficient (ADC) values in cervical cancers To measure serial apparent diffusion coefficient (ADC) values for cervical cancer before,
during and after chemo radiotherapy. To correlate the ADC values with loco...
Methods and materials
Study was approved by an independent ethical committee.
30 patients with carcinoma cervix,
who underwent chemo radiation therapy were examined with pelvic MRI and DWI before initiation of chemoradiation,
after completing external beam radiotherapy and following completion of brachytherapy with a 1.5-T MRscanner and a 16 channel torso coil. MR Imaging protocol consisted of pulse sequences,
with and without contrast,
with parameters as shown in Table 1&2. Table 1 Parameters T1 T2 T2 CERVIX...
Most of the patients were among 41-60 years (63.3 %),
with mean age of 51.63±9.63 years . Distribution of patients according treatment type Treatment No.
of patients(n=30) % CCRT 22 73.3 Neoadjuvant chemotherapy+CCR 8 26.7 Total 30 100.0 Distribution of patients according to treatment response Response group No.
of patients(n=30) % Complete Response 2 6.7 Good Response 17 56.7 Partial Response 11 36.7 Total 30 100.0 Pre,
mid and post treatment comparative response evaluation of tumour size,...
The addition of diffusion weighted imaging to the conventional magnetic resonance imaging protocol allows precise assessment of uterine cervical carcinoma,
from lesion detection and characterization to staging of tumor.
When used in conjunction with apparent diffusion coefficient mapping ,
diffusion weighted imaging is a powerful tool with the potential for early and accurate prediction ,
assessment and monitoring of response to chemo radiation therapy. Based on our data we found that: Most...
Dr Prachi Kala,
MD. Sectional Imaging division,
Department of Radiology, Vydehi institute of medical sciences,
India. email@example.com Dr Vidya Bhargavi, Resident,Department of radiology, Vydehi institute of medical sciences,
India. Dr Rohini Avantsa,
MD. Department of radiology, Vydehi institute of medical sciences,
1. Chen Jianyu,
YangZehong. The utility of diffusion-weighted MR imaging in cervical cancer .
European Journal of Radiology 74 (2010) 101–106. 2. Evis Sala,
The role of dynamic contrast enhanced and diffusion weighted magnetic resonance imaging in the female pelvis.
European Journal of Radiology 76 (2010) 367 –385. 3. Hyun Su Kim,
Chan Kyo Kim,
Evaluation of therapeutic response to concurrent chemoradiotherapy in...