The purpose of this paper was to assess tumor response after the 2nd cycle of neaodjuvant chemotherapy (NACT) according to: 1.) Standardized assessment tool – RECIST, based on purely morphologic changes – tumor diameter change, with the response assessment categorization assigned according to the percentage of the change in the sum of the target diameters [1], 2.) Apparent diffusion coefficient (ADC), based on the diffusion-weighted imaging (DWI), i.e., the change in ADC value initially and upon the completion of the 2nd cycle of the standardized...

Fifty patients (N=50) with histologically confirmed invasive ductal carcinoma (IDC) were analyzed on MRI (1.5 T Magnetom Avanto, Siemens Medical Solutions, Erlangen, Germany; Standardized diagnostic protocol: T2W STIR, T2W-TSE, T1W-TSE, DWI, dynamic 3D-FLASH enhanced; Contrast medium: Gd-DTPA, Magnevist, Bayer Schering Pharma, Berlin, Germany): - Before the initial course of NACT - After the 2nd cycle of NACT According to the predefined endpoints: 1.) RECIST – Response evaluation criteria in solid tumors, version 1.1 (RECIST 1.1): the unidimensional measuring tool, defining and further evaluating the largest...

The average tumor size initially in R and NR (as shown in Table 1), was not significantly different: 2.99+/-0.57 cm vs. 3.33+/-0.49 cm; p>0.05 The difference in ADC between R and NR, was considered highly statistically significant initially: 1.004+/-0.009 mm2/s x 10-3 vs. 0.840+/-0.134 mm2/s x 10-3; p=0.0001 RESPONDERS: After the 2nd cycle of NACT, ADC value increased significantly in R: 1.004+/-0.009 vs. 1.284+/-0.005; p=0.05 and the change was +27.89% (Fig. 1, 2). Although the change in tumor size according to RECIST in R was...

In the two subgroups: R and NR – the initial tumor size was not considered statistically significant (p>0.05), therefore the comparison of the morphologic criteria, was performed in the two subgroups of patients with the tumors of similar size. The initial ADC value differed significantly between the two subgroups: R vs. NR (p=0.0001). It was noted that the ADC value changed in R after the 2nd cycle of NACT and the change was slightly higher than the predefined cut-off value of 27% for R, based...

Ass. Pr. Mirjan M. NADRLJANSKI, MD, PhD1, 2 1Head of Dept. for Breast Imaging,Dept. of Diagnostic Imaging, Institute of Oncology and Radiology of Serbia (IORS), Pasterova 14, 11000 Belgrade, Serbia; [email protected] 2 Dept. of Radiology, School of Medicine, University of Belgrade, Belgrade, RS

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