To compare Contrast-Enhanced Spectral Mammography (CESM) and Contrast-Enhanced MRI (CE-MRI)in breast cancer response to chemotherapy.
Methods and materials
43 consenting women with in situ,
lobular or ductal carcinoma and with indication ofneoadjuvant chemotherapy (NAC) were enrolled into this prospective study between October 2012 andOctober 2014. The patients underwent CESM and CE-MRI before,
after the first NAC cycle and after the endof NAC.
29 patients completed the therapy up to October 2014. Response to therapy was evaluated for eachpatient using the variation of the largest dimension of malignancies measured on CE-MRI and CESM imagesets....
Pearson correlation coefficients between CESM and CE-MRI measurements were 0.982,
0.946 and 0.894 and paired t-test p-values were 0.71,0.20 and 0.43,
during and after NAC. P-values show that there was no statisticaldifference between measurement sets with CESM and MRI at each stage. Clinical outcomes (response ornon-response to chemotherapy) with CESM and CE-MRI were identical for 28 over 29 patients.
CESM and MRI lesion size measurements were highly correlated and in strong agreement. CESM may be an alternative to CE-MRI in assessing response to chemotherapy in patients with breastcancer.
Dromain C , Thibault F , Muller S , Rimareix F , Delaloge S , Tardivon A , Balleyguier C . Dual-energy contrast-enhanced digital mammography: initial clinical results. Eur Radiol. 2011 Mar;21(3):565-74.
doi: 10.1007/s00330-010-1944-y. Dromain C , Thibault F , Diekmann F , Fallenberg EM , Jong RA , Koomen M , Hendrick RE , Tardivon A , Toledano A . Dual-energy contrast-enhanced digital mammography: initial clinical results of a multireader,
multicase study. Breast Cancer Res. 2012 Jun...