Association between retinoblastoma tumour size and tumor extent

This poster is published under an open license. Please read the disclaimer for further details.

Congress:

ECR 2015

Poster Number:

B-0527

Type:

Scientific Paper

Keywords:

Paediatric, Eyes, Oncology, MR, Image manipulation / Reconstruction, Experimental, Imaging sequences, Diagnostic procedure, Outcomes analysis, Metastases, Cancer, Pathology

Authors:

M. C. de Jong¹, F. van der Meer¹, S. Göricke², H. Brisse³, P. Galluzzi⁴, P. Maeder⁵, A. Moll¹, J. A. Castelijns¹, P. De Graaf¹; ¹Amsterdam/NL, ²Essen/DE, ³Paris/FR, ⁴Siena/IT, ⁵Lausanne/CH

DOI:

10.1594/ecr2015/B-0527

DOI-Link:

https://dx.doi.org/10.1594/ecr2015/B-0527

Fig. 1: Examples of tumour volume and diameter determination. Schematic representation...

Fig. 2: Receiver operator curves of tumor volume (red) and diameter (blue) for the...

Fig. 3: Receiver operator curves of tumor volume (red) and diameter (blue) for the...

Purpose

To assess the association between intraocular retinoblastoma tumour size measured with magnetic resonance imaging (MRI) and histopathologically determined metastatic risk factors (postlaminar optic nerve invasion [PLONI] and massive choroidal invasion).

Methods and materials

This study was performed according to the STARD (standards for reporting of diagnostic accuracy) statement.This retrospective study included 370 consecutive retinoblastoma patients (375 eyes) who underwent baseline MRI followed by primary enucleation. Tumour sizes (maximum diameter and gross volume) were measured independently by two observers (figure 1). Receiver operator curve (ROC) and logistic regression analysis were used to analyse the data and to evaluate potential confounders.

Results

For PLONI, ROC analysis yielded areas under the curve (AUC) of 0.77 (95% CI 0.70–0.85) vs. 0.78 (0.71–0.85), respectively for volume and diameter. Massive choroidal tumour invasion showed AUCs of 0.67 (0.57–0.77) and 0.70 (0.59–0.80), see figures 2 and 3. Logistic regression analysis showed that tumour size was the main predictor of these metastatic risk factors. The risk of PLONI was minimal (<1%) below 0.88 cm3 or 14 mm, whereas the risk was substantial (>25%) above 1.8 cm3 or 17.2 mm. Across the different tumour...

Conclusion

Tumour size is a good predictor of postlaminar optic nerve tumor invasion and to a lesser extent also of massive choroidal tumor invasion. Across the tumour size categories the risk of massive choroidal invasion is more evenly distributed. Tumour diameter and volume both performed similarly, but volume can be obtained more reliably.

Personal information

References

1. Shields CL, Shields JA, Baez KA, et al: Choroidal invasion of retinoblastoma: metastatic potential and clinical risk factors. Br J Ophthalmol 77:544–8, 1993 2. Shields CL, Shields JA, Baez K, et al: Optic nerve invasion of retinoblastoma. Metastatic potential and clinical risk factors. Cancer 73:692–8, 1994 3. Chantada GL, Casco F, Fandiño AC, et al: Outcome of patients with retinoblastoma and postlaminar optic nerve invasion. Ophthalmology 114:2083–9, 2007 4. Bosaleh A, Sampor C, Solernou V, et al: Outcome of children with retinoblastoma and isolated...