Purpose
The purpose of our study was to find out the diagnostic accuracy of Double Inversion Recovery sequence compared to FLAIR and T2W_TSE in detection of brain MS plaques.
This concept in the past,
that MS just attack white matter(WM) or was known as a WM disease has been refused duo to some lesions in juxtacortical,
intracortical,
and subpial which has been observed in individuals with MS.
White matter and gray matter lesions have an important role in cognitive performance and the number of detected lesions...
Methods and materials
Fifty five patients were included in our study,
imaging was performed on a 1.5T Philips (Ingenia) MR system in MRI department of Vali_E_Asr hospital_Ghaem Shahr_Iran and using a standard head coil and conventional MRI sequences as well as DIR,
FLAIR,
and T2W_TSE sequences .
Axial planes performed in these three sequences with the same anatomical position and parameters including FOV,
matrix,
Voxel size and Number of signal averaging (NSA).
On DIR sequence it is used two different TI (first TI=3400 ms and second TI=325 ms)...
Results
· In DIR we observed more ICLs compared to both T2W_TSE and FLAIR sequences which is duo to better contrast between lesions and the surrounding GM in the DIR images.
· The optimized contrast between the lesion and normal appearing gray matter (NAGM) produced due to slight attenuation of the signal from cerebral cortex in the DIR images.
· DIR imaging shows higher contrast ratios and delineation between MS lesions and the normal appearing white matter (NAWM) in all anatomic regions compared to FLAIR and...
Conclusion
More MS lesions in number and size can be detected in DIR sequence in comparison with FLAIR and T2_W TSE.
MS lesions will be more countable in DIR sequence compared to FLAIR and T2W_TSE duo to better delineation between MS lesions and white matter/gray matter.
Also,
MRI has an important role in early diagnosis of multiple sclerosis and clinically isolated syndromes (CIS) that may convert to definite multiple sclerosis,
so we strongly recommend to add DIR sequence in the routine MR protocols of MS patients.
Personal information
Fariborz Faeghi,
Phd of medical physics,
Shahid Beheshti University of Medical Science,faculty member of paramedical college,head of Radiology depatment,
Tehran,
Iran,
e-mail:
[email protected]
Zahra Mardan shahi,
MD Radiologist,
Mazandaran University of Medical Science,Sari,
Mazandaran,
Iran,
e_mail:
[email protected]
Zahra Abidi MSC student of medical imaging technology,
paramedical college,
shahid Beheshti University of Medical Science,
Tehran,
Iran,
e_mail :
[email protected]
References
1.
Calabrese,
M.,
De Stefano,
N.,
Atzori,
M.,
Bernardi,
V.,
Mattisi,
I.,
Barachino,
L.,
Morra,
A.,
Rinaldi,
L.,
Romualdi,
C.,
Perini,
P.
and Battistin,
L.,
2007.
Detection of cortical inflammatory lesions by double inversion recovery magnetic resonance imaging in patients with multiple sclerosis.
Archives of Neurology,
64(10),
pp.1416-1422.
2.
Geurts,
J.J.,
Pouwels,
P.J.,
Uitdehaag,
B.M.,
Polman,
C.H.,
Barkhof,
F.
and Castelijns,
J.A.,
2005.
Intracortical Lesions in Multiple Sclerosis: Improved Detection with 3D Double Inversion-Recovery MR Imaging 1.
Radiology,
236(1),
pp.254-260.
3.
Elnekeidy,
A.M.,
Kamal,
M.A.,...