Parkinson's disease (PD) typically manifests with unilateral motor signs and subsequently evolves a number of motor and non-motor symptoms [Hoehn and Yahnr, 2001]. Resting tremor is one of the main Parkinson’s disease (PD) symptoms. Tremor asymmetry is considered a crucial criterion for PD and may influence hemisphere-associated cognitive functions [Erro et al. 2012]. It is still debated whether the lateralization of PD symptoms influences the way of future disease progression, especially concerning non-motor symptoms development and the role of DMN in this process [Erro et...

Group of 30 right-handed PD patients (12F, 46-74 y.o.) was studied by fMRI with 1.5T SIGNA (GE, USA). According to the UPDRS tremor severity and sidedness, it was divided into four subgroups. Left side tremor: GLlignt (7 patients, 2F, tremor 0-1), GLsevere (11 patients, 5F, tremor 2-4). Right side tremor: GRlignt (6 patients, 3F, tremor 0-1), GRsevere (6 patients, 1F, tremor 2-4). Total brain activation was analysed for GLlignt, GLsevere, GRlignt, GRsevere. Right-hand finger tapping task was used for fMRI activation. Also, brain activation during...

fMRI data showed the common pattern of brain activation for all studied subjects: bilateral primary (M1S1), premotor, supplementary motor cortex, thalamus and cerebellum Fig. 1. Increase of activation volume(voxels)/ΔBOLD (%) amplitude was shown in (GRlight>GRsevere>GLsevere>GLlight): (3736/2.22, 3281/1.96, 1664/1.36, 1274/1.33) respectively Fig. 2. Activation of the subthalamic region was shown in GRlight, GRsevere during the movement execution. Decrease of M1S1 activation was shown in GRsevere Fig. 1. Bilateral cortex activation in PD patients under unilateral motor task execution is explained by plasticity changes in brain motor...

Tremor severity and sidedness influences brain activation pattern and BOLD response in PD patients. We identified PD symptoms laterality dependent STN activation peculiarities. Obligatory left STN activation in AMT suppose it’s role in motor command switching. Bilateral STN activation during the movement execution supports it’s proposed role as a motor error correction node.

Oleksii Omelchenko Department of Human and Animal Physiology Institute of Biology Taras Shevchenko National University of Kyiv Acad. Hlushkova pr-t, 2, Kyiv, 03022, UKRAINE @ : [email protected] ___________________________________ Zinayida Rozhkova, PhD Department of Radiology Medical Clinic BORIS Bazhana pr-t, 12A, Kyiv, 02140, UKRAINE @ : [email protected] ___________________________________

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