Diagnostic accuracy of biparametric vs multiparametric MRI in prostate cancer local staging

This poster is published under an open license. Please read the disclaimer for further details.

Congress:

ECR 2017

Poster Number:

C-2901

Type:

Scientific Exhibit

Keywords:

Oncology, Pelvis, Genital / Reproductive system male, MR, MR-Diffusion/Perfusion, Computer Applications-Detection, diagnosis, Imaging sequences, Staging, Pathology, Cancer, Neoplasia

Authors:

F. Misischi, R. Faletti, F. Gentile, P. Cimpoesu, G. Calleris, L. Molinaro, J. Giglio, P. Gontero, P. Fonio; Turin/IT

DOI:

10.1594/ecr2017/C-2901

DOI-Link:

https://dx.doi.org/10.1594/ecr2017/C-2901

Fig. 1: Diagnostic parameters of F-EPE in biparametric and multiparametric MRI

Fig. 2: Diagnostic parameters of NF-EPE in biparametric and multiparametric MRI

Fig. 3: Diagnostic parameters of SV in biparametric and multiparametric MRI

Fig. 4: Patient with a focal lesion of 16 mm maximal extension at the mid-level in the...

Aims and objectives

MRI diagnostic performance in detection of prostate cancer is widely demonstrated although MR in local staging is still debated. Our aim was to compare the performance of biparametric (T2WI+DWI) and multiparametric MRI (T2WI+DWI+DCE) in prostate cancer local staging.

Methods and materials

Fifty-seven patients with pre-operative MR were retrospectively evaluated. Patients were enrolled by using the following inclusion criteria: (a) pre-operative multiparametric MRI (T2WI+DWI+DCE); (b) pre-operative MRI performed at least three weeks after prostate biopsy; (c) radical prostatectomy within maximum of 6 months after MR study. All imaging studies were performed with a 1,5 Tesla MR scanner (Achieva, version 2.6; Philips Medical Systems, DA Best, Olanda) with a Torso Cardiac phased array 32 channels coil. No endorectail coil were used. An intramuscolar injection of 20 mg of...

Results

The inter-observer agreement was good (κ=0,71±0,15). There were no statistically significant differences between biparametric and multiparametric MRI in the performance of MR in local staging. Sensitivity of biparametric and multiparametric MRI for F-EPE was respectively 65,4% and 55,8% (p=0,32); specificity was 87,8% and 91,1% (p=0,47); positive predictive value (PPV) was 75,6% and 78,4% (p=0,76); negative predictive value (NPV) was 81,4% and 78,1% (p=0,55); accuracy was 79,6% and 78,2% (p=0,77). The diagnostic parameters of F-EPE are summarized in Table 2 and Figure 1. Focal extraprostatic extension...

Conclusion

In our study multiparametric prostate MRI did not increase the accuracy of capsular invasion and extracapsular tumor extension compared to biparametric analysis. Prostate cancer MR local staging accuracy is higher for extensive “non-focal” extracapsular tumor extension than for limited “focal” capsular invasion and seminal vesicles involvement.

Personal information

References

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