Aims and objectives
To evaluate the ability of quantitative spectral CT parameters in assessing degree of differentiation of gastric adenocarcinoma and its correlation with clinicopathological features.
Methods and materials
In all,
153 patients with histologically confirmed gastric adenocarcinoma underwent dual-phase enhanced spectral CT examination.
Iodine concentration value in each tumor was measured,
and further standardized against that in aorta.
The correlations among quantitative spectral CT parameters with age,
gender,
location,
maximum diameter were analyzed.
Receiver-operating characteristics (ROC) analysis was conducted to determine the optimal thresholds,
the sensitivities and specificities for discrimination of tumorous differentiation degree.
Results
Measurements by readers 1 and 2 for ICC-AP,
ICC-PP,
nICC-AP and nICC-PP of the gastric adenocarcinoma were 0.944,
0.991,
0.910 and 0.897,
with 95% CI 0.942–0.946,
0.899–0.993,
0.901–0.921 and 0.895–0.899,
respectively.
The maximum diameter,
IC and nIC value on the dual phase of poorly differentiated tumors were statistically greater than those of moderately differentiated ones (P<0.05).
There was significant correlation between maximum diameter and nICPP (r=0.400,
p=0.023) in cardia and fundus groups,
and in pylorus and antrum group(r=0.413,
p=0.032).
The area under the curve(AUC),
the...
Conclusion
Quantitative spectral CT parameters were helpful in assessing differentiation degree in patients with gastric adenocarcinoma,
nIC values are more valuable than IC.
Correlation between the maximum diameter and quantitative parameter values differ between different tumor sites.
Personal information
Jing LI,
PhD.
Department of Radiology,
the First Affiliated HOspital of Zhengzhou University.
Pan LIANG,
PhD.
Department of Radiology,
the First Affiliated HOspital of Zhengzhou University.
Jianbo GAO,
PhD.
Department of Radiology,
the First Affiliated HOspital of Zhengzhou University.
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