MRI features of recurrent/progressive meningiomas having increased 18F-choline uptake on PET

Congress:

ECR 2018

Poster Number:

C-2586

Type:

Educational Exhibit

Keywords:

Multidisciplinary cancer care, Cancer, Perception image, Imaging sequences, PET-CT, MR, Neuroradiology brain

Authors:

J. E. Gutierrez Alliende¹, A. Gallardo Alcañiz², A. Fernandez Leon², M. D. V. Camacho Marti², A. Lozano², J. E. Méndez Escalante², C. J. De Quintana Schmidt ², I. Carrio Gasset ², B. Gomez-Anson²; ¹Barcelona /ES, ²Barcelona/ES

DOI:

10.1594/ecr2018/C-2586

DOI-Link:

https://dx.doi.org/10.1594/ecr2018/C-2586

Table 1

Table 2

Fig. 1: Figure 1 shows a well-circumscribed extra axial mass lateral and attached to...

Table 3: TABLE 3 shows the gender, age, histology and cellularity-index (KI-67) of these...

Learning objectives

To study magnetic resonance imaging (MRI) features of recurrent/progressive meningiomas showing increased uptake of 18F-choline on positron emission tomography (18F-choline-PET).

Background

Meningiomas are non-glial neoplasms originating from the meningocytes or the arachnoid cap cells of the meninges. They are the most frequent primary brain tumors and represent approximately 20-30% of all primary intracranial neoplasms [1-2] with an annual incidence of about 4-5 per 100.000 individuals [3]. The incidence increases progressively with age, change by race (with a black to white ratio of 2:1 [7]) and sex, being more common in women (female to male ratio of about 3:1 [8]). Meningiomas can be multiple in 5-40% of...

Findings and procedure details

42 patients (15 men and 27 women, average age 58 years) having meningiomas that were surgically treated and clinically followed-up with MRI at our institution during the period 2009-2017 were included. Of these, 6 patients having increased uptake on 18F-choline on PET (3 men, 3 women, average age 60.6 years) and recurrent/progressive meningiomas were identified. Of these 6 patients, histology demonstrated: 2 meningotheliomatous meningiomas (WHO Grade I) and 4 atypical meningiomas (WHO Grade II) with a mean cellularity-index (KI-67) of 7.6% (range 3-15) ( Table...

Conclusion

Recurrent/progressive meningiomas (RPM) having increased 18F-choline uptake on PET tend to show a pattern of signal changes/appearance on MRI similar to other malignant primary brain tumors. This includes high T2, low T1, low ADC values and no decreased SWI, findings that may reflect the high cellularity/atypia present in RPM. Since our study is small, there is further need for larger evidence with F18-choline PET in meningiomas, and for longitudinal studies.

Personal information

References

1. Perry A LD, Scheithauer BW, Budka H, von Diemling A. Meningiomas. In: Louis DN OH, Wiestler OD, editor. World Health Organization Classification of Tumours of the Central Nervous System. 4. ed.Lyon: IARC 2007. p. 164–72. 2. Riemenschneider MJ, Perry A, Reifenberger G. Histological classification and molecular genetics of meningiomas. Lancet neurology. 2006; 5(12):1045–54. Epub 2006/11/18. doi:10.1016/s1474-4422 (06)70625-1PMID:17110285. 3. CBTRUS (2005). Statistical report: primary brain tumors in the United States, 1998-2002. Central Brain Tumor Registry of the United States. 4. Durand A, Labrousse F, Jouvet...