Learning objectives
To describe the main modifications in the updated Head and Neck TNM classification with relevance to Radiology,
providing significant examples.
Background
Head and neck cancer (HNC) constitute a heterogeneous group of upper aerodigestive tract malignancies originated in the lip,
oral cavity,
hypopharynx,
oropharynx,
nasopharynx or larynx,
that togetherconstitute the seventh most common cancer worldwide.
Oral cavity and laryngeal cancers are the most common head and neck cancers globally,
and the squamous cell carcinoma represents 89% of them.
Although tobacco and alcoholconsume had been historically the main risk factors to develop HNC,
human papillomavirus (HPV) has been recognized over the past decade as another important cause of...
Findings and procedure details
Main modifications in the updated Head and Neck TNM classification with relevance to radiologist:
Separate classifications for clinical and pathological neck nodes
New classification for high-risk human papillomavirus-associated cancer of the oropharynx (Oropharynx p16+).
T or N modifications: .Oral cavity .Nasopharynx .Inclusion of extranodal extension
NEW CLASSIFICATION OROPHARYNX P16+.
The key update is the new staging for high risk human papillomavirus (HPV)-related oropharyngeal cancer distinguishing it from oropharyngeal cancer due to other causes.
The incidence of HPV-HNC has risen radically in the last decades,
in...
Conclusion
The 8th edition of the TNM Classification of Malignant Tumours introduces significant modifications for Head and Neck cancer.
Radiologist should be aware of the updated classification system to provide useful and accurate staging information.
References
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Rettig E,
D’Souza G.
Epidemiology of Head and Neck Cancer.
Surgical Oncology Clinics of North America.
2015;24(3):379-396.
(2).
Crescenzib D,
Laus M,
Radici M,
Croce A.
TNM classification of the oral cavity carcinomas: some suggested modifications.
Otolaryngologia Polska.
2015;69(4):21-30.
(3) Pentenero M,
Gandolfo S,
Carrozzo M: Importance of tumor thickness and depth of invasion in nodal involvement and prognosis of oral squamous cell carcinoma: a review of the literature.
Head Neck 2005;27:1080–1091.
(4).
Lydiatt,
W.,
Patel,
S.,
O'Sullivan,
B.,
Brandwein,
M.,
Ridge,
J.,
Migliacci,...