Learning objectives
The purpose of our study is to present the vital role of imaging techniques (radiography,
computed tomography and magnetic resonance imaging) in assessing and in following – up Langerhans cell histiocytosis in childhood.
Background
Langerhans cell histiocytosis (LCH) is a rare disease involving clonal proliferation and migration of dendritic antigen-presenting histiocytes,
a form of white blood cell found in healthy people that is supposed to protect the body from infection.
In people with LCH,
these cells multiply excessively and are capable of infiltrating almost any tissue or organ,
causing tumors called granulomas to form.
The etiology of LCH is unknown.
It may manifest at any age usually children between 1 and 3 years.
Aggressive forms of the disease are...
Findings and procedure details
Between 1991 and 2017,
30 patients (age from 2m – 13y) with LCH were treated in our hospital.
Our study included:
24 patients with single-system and
6 patients with multi-system disease.
The most frequent LCH site was the bones (23 children):
Single bone Fig. 2 ,
Fig. 3,
Multiple bones Fig. 4 ,
Fig. 5 ,
Fig. 6 ,
Fig. 7 ,
Fig. 8 ,
Fig. 9 ,
Fig. 10 .
Three children suffering from LCH presented diabetes insipidus Fig. 11 and eight children had...
Conclusion
Surgery,
chemotherapy and radiotherapy have been used alone or in combination to treat LCH.
Familiarity with the imaging appearances of histiocytic disorders is crucial for appropriate patient management.
References
Wei-Fang Chang,
Yi-Chih Hsu,
Yi-Der Wu,
Chun-Lang Kuo,
Guo-Shu Huang.
Localized Langerhans cell histiocytosis masquerading as Brodie’s abscess in a 2-year-old child: a case report.
EXCLI Journal 2016;15:33-37.
Daniel Forlino,
Patricio Manzone,
Matilde Cristina Gomel,
María Beatriz Nicoli,
Cesy Pedrini.
Craniofacial and skull base findings in Langerhans cell histiocytosis in pediatric patients.
RAR - Volumen 77 - Número 1 – 2013.
S Hayes,
S Rahman,
B Vadgama,
R Salib,
T Mitchell.
A Case Of Langerhans’ Cell Histiocytosis Of The Temporal Bone Masquerading As Acute Mastoiditis....