Aims and objectives
Endovascular treatment (EVT),
as a minimally invasive therapy,
treats only a diseased vessel segment.
However,
dilatation with high pressure balloons and implantation of stents cause periprocedural injury of the arterial wall by endothelial denudation,
as well as intimal and medial damage [1].
These injuries are followed by inflammatory response that often ends with neointimal hyperplasia,
a major culprit for long-term EVT failure [2].
Fig. 1
It has been reported that higher postprocedural levels of inflammatory biomarkers indicate a higher risk for restenosis [3,4].
Both C-reactive...
Methods and materials
Study design: observational single-center cohort study conducted between June 2014 and April 2017.
Study population:
Inclusion criteria: patients with PAD referred by vascular surgeon for diagnostic angiography and/or endovascular treatment.
Fig. 2
Exclusion criteria: ongoing hemodialysis; malignant disease; history of surgery,
myocardial infarction or coronary endovascular intervention in the past 3 months; history of endovascular intervention on the peripheral arteries in the last 2 weeks; ongoing immunosuppressant therapy; chronic inflammatory disease; clinical or laboratory signs of acute infection (baseline CRP ≥10 mg/l).
Patients who underwent...
Results
Endovascular procedures summary: PTA was performed in 44 (72%) and stenting in 27 (38%) patients.
The median balloon inflation time during PTA was 360 seconds (s) (interquartile range [IQR] 180-431.3).
Balloon inflation time for a single patient was calculated as a sum of duration of all balloon inflations performed during vascular intervention.
The median length of PTA treated segment was 8 cm (IQR 6-15) and the median stented segment length was 5 cm (IQR 4-6).
Postprocedural CRP and fibrinogen increase: there was significant increase in...
Conclusion
In the current study,
CRP level increase showed positive correlation with PTA treated segment length,
balloon inflation time and stented segment length suggesting that the extent of periprocedural arterial injury correlates with vascular inflammatory response.
However,
we found no such correlation for fibrinogen.
Significant increase was detected in both CRP and fibrinogen levels in patients following EVT.
Similar increase in inflammatory biomarkers was found after EVT in previous studies,
both on coronary and peripheral arteries [3,8–11].
In the control group,
the increase in CRP and...
Personal information
Tajana Turk,
MD
Faculty of Medicine,
University of Osijek,
Department of diagnostic and interventional radiology,University Hospital Osijek.
Huttlerova 4
31000 Osijek
Croatia
Telephone: ++385912028986
E-mail:
[email protected]
This poster is based on scientific paper that has been accepted for publication in ACTA CLINICA CROATICA.
References
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Vascular Inflammation and Percutaneous...