Measurement of cerebral perfusion with arterial spin labelling in normocapnic and hypercapnic conditions

Congress:

ECR 2018

Poster Number:

C-1381

Type:

Scientific Exhibit

Keywords:

CNS, Neuroradiology brain, MR-Functional imaging, MR-Diffusion/Perfusion, Imaging sequences, Normal variants, Haemodynamics / Flow dynamics

Authors:

A. N. Sergeeva¹, E. Seliverstova², S. Morozova¹, E. I. Kremneva¹, Z. Gadzhieva¹, M. Zabitova¹, B. Akhmetzianov¹, L. Dobryinina¹, M. Krotenkova¹; ¹Moscow/RU, ²Krasnogorsk/RU

DOI:

10.1594/ecr2018/C-1381

DOI-Link:

https://dx.doi.org/10.1594/ecr2018/C-1381

Fig. 2: Mask of activation regions combined with CBF map.

Fig. 1: ASL imaging of cerebral blood flow

Fig. 3: 1a - dorsolateral prefrontal cortex and anterior prefrontal cortex 1b -...

Aims and objectives

Background: Arterial spin labelling (ASL) is a viable alternative to BOLD fMRI as a technique in which cerebral blood flow (CBF) is directly measured and quantified in absolute physiological units. Purpose:To explore ASL-MRI-based activation for assessment of regional CBF in areas of neuronal activations in healthy individuals performing the Stroop-test at normocapnic and hypercapnic conditions.

Methods and materials

Ten healthy subjects, age 51-60, underwent pASL (pseudocontinuous arterial spin labelling) sequence on MRI-scanner 3.0 T. We applied a simple block task using the Stroop color-word test on hypercapnia with gas-oxygen mixture(СО2 6 %,О2 21 %, N2 73 %)and normocapnia. CBF was calculated using SPM8, ASLtbx and ITK SNAP.

Results

pASL-based analysis using modified Stroop test paradigm showed activation of constituent regions of executive network: dorsolateral prefrontal cortex, anterior prefrontal cortex, supplementary motor area, and of regions in occipital cortex. For CBF references were chosen in areas in temporal lobes without activation. CBF analysis showed significant increase in hypercapnic vs normocapnic conditions in activation regions: 113.7 [106.9; 119.2] vs 98.28 [92.5; 101.8] in occipital cortex, 116.3 [104.9; 120.3] vs 94.6 [92.5; 102.1] in dorsolateral prefrontal cortex, 128.3 [110.5; 130.9] vs 100.11 [96.9; 105.0] in supplementary...

Conclusion

pASL provides reliable results for CBF assessment in healthy volunteers. Suggested post-processing algorithm allows CBF measurement in specific ROIs and may be further used for estimating neurovascular coupling and cerebrovascular reserve in patients with small vessels disease.

Personal information

References

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