Data analysis of lung cancer patients with an age of 40 years old or more detected by LDCT screening

Congress:

ECR 2019

Poster Number:

C-1306

Type:

Scientific Exhibit

Keywords:

Image verification, Epidemiology, Cancer, Efficacy studies, Diagnostic procedure, Computer Applications-Detection, diagnosis, PACS, CT, Conventional radiography, Oncology, Management, Lung

Authors:

Y. Jin, N. Wu; Beijing/CN

DOI:

10.26044/ecr2019/C-1306

DOI-Link:

https://dx.doi.org/10.26044/ecr2019/C-1306

Fig. 1: lung cancer detection rate in different age groups

Table 1: The clinical, pathology and radiology data of lung cancers detected by LDCT

Table 2: Tumor Markers results of lung cancer cases in different age groups

Fig. 2: CEA results of lung cancer cases in different age groups

Aims and objectives

Explore the application value of LDCT lung cancer screening in different age groups through analysis of clinical, pathology and radiology data, thus improving the effectiveness of LDCT lung cancer screening.

Methods and materials

10033 participants had LDCT lung cancer screening in the Cancer Hospital were involved and divided into 3 groups by age(40-49, 50-59 and ≥60years old group). The detection rate was calculated for overall and individual groups, clinical, pathology and radiology data were also collected and analyzed for group differences.

Results

The overall lung cancer detection rate with LDCT was 0.6% (64 cases). The detection rate for 40-49, 50-59 and ≥60years old group was 0.4%, 0.6%, 1.2% respectively. The detection rate among groups was significantly different(P=0.001) and increased age-dependently(P=0.002). 61 adenocarcinoma cases were detected (95%), and the proportion of stage I, II, III, IV was 88%,5%, 5%, 2% respectively, with more stage III/IV patients in ≥60years old group. ≥60years old group showed the most CEA rise with an odds ratio of 2.0 compared with 40-49 years...

Conclusion

The LDCT lung cancer detection rate increased significantly with age. 40-49years old group detection rate is lower than overall. ≥60years old group had the highest detection rate but stage III or IV patients proportion rised. Thus, we recommended it LDCT lung cancer screening for ≥50 years old to guarantee more early stage lung cancer cases being detected. LDCT lung cancer screening for ≥60years old could combine with CEA. This study detected 88% stage I lung cancers.

Personal information

Y. Jin, N. Wu.Diagnostic Radiology, Peking Union Medical college/ Chinese Academy of Medical Sciences, Cancer Hospital/ Institute - Beijing/CN

References

Chen W, Zheng R, Baade PD, et al. Cancer Statistics in China, 2015[J]. CA Cancer J Clin. 2016, 66(2): 115-32. Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012[J]. Int J Cancer. 2015,136(5): E359-86. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015[J]. CA Cancer J Clin. 2015, 65(1): 5-29. International Early Lung Cancer Action Program Investigators, Henschke CI, Yankelevitz DF, et al. Survival of patients with stage I lung cancer detected on...