Learning objectives
To evaluate the role of PET/CT in detecting second primary and subsequent tumors and also to demonstrate the influence on the treatment management in these patients.
Background
Multiple primary cancers are usually defined as primary malignant tumors of different histological origins in one person.
Recently,
there has been an increase in the number of patients diagnosed with multiple primary cancers.
Last data suggest that the incidence of 2nd primary synchronous or metachronous tumor is increasing and reported as high as 10%.
Meta analyses show the frequency of second tumor (SPT) as 3-5%,
a third tumor (TT) as 0.5%,
and a fourth tumor (QT) as 0.3%.
This trend can be attributed to improved...
Findings and procedure details
Twenty patients with clinically proven at least one malignancy were evaluated and followed up for two- year period.
All patients were scanned on GE Discovery PET/CT 16 slices scanner from the top of the head to mid-thigh.
Study was performed one hour after injection,
using the weight adjusted activity,
hydration of patients with diuretic
stimulation and oral/i.v contrast intake.
As second malignancies we detect five gastrointestinal (25%),
five urogenital cancers (25%),
four pulmonary carcinomas (20%),
three head and neck squamous cell carcinoma (15%),
two lymphoma...
Conclusion
Multiple primary cancers are not common,
but it is believed that the incidence is increasing.
The interaction between them is complex and not yet fully understood.
Since in patients with multiple cancers,
the focus is mainly on the primary disease,
there is a higher likelihood of missing incidental co‑existence of another primary malignant lesion.
That way every cancer patient,
whether in complete clinical remission,
should be regularly and thoroughly followed through the entire life span.
Because of the combination between metabolic and morphologic information provided...
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