Mild traumatic brain injury (mTBI) occupies one of the first places in children injuries. Patients with mTBI may suffer headache, dizziness memory loss and short-term loss of consciousness in acute stage of injury [1]. However, in patients with mTBI there is usually an absence of structural lesions revealed by MRI studies in particular. That’s why mTBI neurobiological mechanisms are not fully understood. Resting-state functional MRI (rsfMRI) allows us to obtain new information on functional connectivity patterns of human brain. This technique is especially useful to...

Patients:34 MR negative participants were studied in age from 12 to 17 years (mean age – 14.5 years). Group of patients consisted of 17 children with mild traumatic brain injury in acute stage. 17 age-matched healthy volunteers comprised control group. Materials and methods: All studies were performed at Phillips Achieva 3.0T MRI scanner using 32-channel head coil. fMRI studies were conducted using EPI BOLD (TR = 3000, TE = 30, EPI factor = 240, slice thickness = 4 mm, NSA = 1, 80 dynamics, total...

No statistically significant differences in correlation strength between DMN parts were observed in two groups (fig.1). Seed-based analysis revealed absence of statistically significant neural correlations (p = 0,39) between DMN and cerebellum structural parts: inferior and superior semilunar lobules and flocculus (fig.2). While in control group analysis showed statistically significant correlations (p < 0,05) in connectivity of respective areas (fig.3).

One of the most common symptoms of mTBI is dizziness as a result of impaired movements coordination [4]. Cerebellum plays an important role in motor control in human brain. Flocculus as an essential cerebellum part (see Figure 3) plays an important role in the vestibulo-ocular system which is involved in the learning of basic motor skills in the brain [5]. Flocculus aids in the synchronization of eye and motor functions in order for the visual field and the motor skills to function together [6]. Flocculus...

1. Bigler E.D. Neuropsychology and clinical neuroscience of persistent post-concussive syndrome. J Int Neuropsychol Soc 2008;14(1):1–22. 2. Mayer A.R. Functional connectivity in mild traumatic brain injury. Hum Brain Mapp 2011 32, 1825–1835. 3. Whitfield-Gabrieli S. Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. Brain Connect. 2012; 2(3): 125-41. 4. Fife, T.D. Persistent vertigo and dizziness after mild traumatic brain injury. Ann N Y Acad Sci. 2015 Apr; 1343: pp 97-105. 5. Ito, M. Cerebellar Control of the Vestibulo-Ocular Reflex--Around the Flocculus Hypothesis....