Aims and objectives
Our purpose was to investigate the MR features that could lead to recurrence after radical surgery for pancreatic neuroendocrine tumors (PNETs).
Methods and materials
Sixty patients with PNETs undergoing radical surgery from 2009 to 2018 were recruited into this retrospective study.
MR imaging features（pancreatic atrophy， tumor shape,
tumor size and lymph node metastasis）,
tumor grading of WHO 2017,
and intravascular tumor embolus on samples were assessed by Cox proportional hazard ratio regression to confirm predictors of progression-free survival (PFS).
The cumulative recurrence rate was calculated by the Kaplan-Meier method and the log-rank test was...
Recurrence of PNETs was found in 10 of 60 patients during the follow-up period,
and the overall estimated 3-year PFS was 78.7%.
Pancreatic Atrophy (P=0.002) and irregular shape (P = 0.013) were independently associated with poor PFS.
The PFS of pancreatic atrophy group was significantly lower than the non-pancreatic atrophy group when the age of patients≤53(P=0.004).
The PFS of irregular shape was significantly lower than round shape(P=0.004).
The PFS of G1 group was better than the G3...
The irregular tumor contours and pancreatic atrophy may be MRI predictors of poor prognosis in PNETs after curative surgery.
Yabin Hu，Department of Radiology,
and Shanghai Institute of Medical Imaging,
ADDIN NE.Bib  Ohmoto A,
Pancreatic Neuroendocrine Neoplasms: Basic Biology,
Current Treatment Strategies and Prospects for the Future.
INT J MOL SCI 2017;18(1):143.  Guilmette JM,
Neoplasms of the Neuroendocrine Pancreas: An Update in the Classification,
and Molecular Genetic Advances.
ADV ANAT PATHOL 2018.  Birnbaum DJ,
Surgical Management of Advanced Pancreatic Neuroendocrine Tumors: Short-Term and Long-Term...