Aims and objectives
There are different phenotypic differences between cancers of the same organ which can only be visualized using radiographic imaging.
2] Breast carcinoma is the most common cancer with a reported prevalence of 1 in 9 women in Pakistan.
 Early and accurate detection of breast cancer and delineation of its histologic subtype is crucial to instituting appropriate treatment.
In the era of personalized medicine,
tailoring therapies to specific molecular and genomic profiles of cancers is...
Methods and materials
A retrospective study was performed at the Dow Institute of Radiology and all women aged 18 years or older were eligible for inclusion.
Data was retrieved using the hospital’s electronic medical record (EMR) system.
All patients who had histopathological confirmation of infiltrative ductal breast carcinoma and who subsequently underwent CT chest for staging were included in the study.
All patients who had either tumour recurrence or previous surgery related to the breast were excluded from...
A total of 32 women with a median age of 48 (interquartile range: 39–55) years were included in the study.
Histologic grading of infiltrating ductal carcinoma was made in accordance with modified Bloom and Richardson classification.
18 (56.2%) and 7 (21.9%) cancers were well,
moderately and poorly differentiated respectively.
histopathological and immunohistochemical features of subjects included in the study are mentioned intable2. Characteristics n (%) Women...
The results of this study suggest that CT texture parameters may be used as imaging biomarkers of histological and immunohistochemical features in infiltrating ductal carcinoma of the breast.
Further studies utilizing different software and with larger sample sizes are required to further validate and standardize these results for routine clinical practice.
DR MUHAMMAD AWAIS ASSISTANT PROFESSOR DOW INSTITUTE OF RADIOLOGY KARACHI,
Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications.
Int J Mol Sci.
2017 Oct 24;18(10).
doi: 10.3390/ijms18102229. 2.
Non-Small Cell Lung Cancer Radiogenomics Map Identifies Relationships between Molecular and Imaging Phenotypes...