Learning objectives
To describe IPMT of the bile duct, a distinct pathologic entity.
To explain its behaviour in different imaging studies and modalities of choice for characterisation.
Background
Intra-ductal papillary neoplasms of bile ducts (IPNB) are mucin producing papillary neoplasms arising from intra-ductal biliary mucosa, a rare variant considered a counterpart of intra-ductal papillary mucinous neoplasm (IPT) of the pancreas, recently added to the WHO classification.
Aetiology is unknown, but its association with hepatolithiasis and Clonochiis suggests chronic biliary inflammation. The main age o presentation is around the 5th and 7th decades of life with no gender predilection. It is thought to have an ethnical predilection since most cases have been described in...
Findings and procedure details
IPNBs usually manifest as intra-ductal masses with bile duct dilation (proximal and sometimes distal); which may be tubular, fusiform or cystic. Imaging appearance depends predominantly on two features; papillary proliferation and mucin production.
The detection of these lesions is based on their size; the most dilated bile ducts are usually the ones containing the tumour lesion, even when it is not radiologically recognisable.
Herein we present 3 cases:
Case 1: (Fig. 1)(Fig. 2)(Fig. 3)
Case 2:(Fig. 4)(Fig. 5)(Fig. 6)(Fig. 7)
Case 3: (Fig. 8)(Fig. 9)...
Conclusion
Intra-ductal papillary neoplasms of bile ducts (IPNB) are rare but aggressive neoplasms arising from the intra-ductal mucosa characterised by papillary formations and mucin production. They are slow growing and multifocal lesions, which cause intermittent obstruction of normal bile flow, generating the clinical symptoms; acute cholangitis, abdominal pain, fever, chills and jaundice.
Diagnosis is challenging due the variability of appearance of the lesions in the several imaging techniques, as well as in size, shape and position. Therefore it is recommendable the use of various imaging techniques...
Personal information and conflict of interest
M. Gredilla; Donostia/ES - Author at Hospital Universitario Donostia M. Leturia Etxeberria; San Sebastian, GIPUZKOA/ES - nothing to disclose A. Serdio; Donostia - San Sebastián/ES - nothing to disclose J. Badiola Molinuevo; SAN SEBASTIAN/ES - nothing to disclose J. Burgos Ruiz; Donostia - San Sebastián/ES - nothing to disclose A. Luis Fernández; Donostia - San Sebastián/ES - nothing to disclose
References
Argha Chatterjee, MD, Camila Lopes Vendrami, MD, Paul Nikolaidis, MD, Pardiip K. Mittal, MD, Adrew J. Bandy, MD, Christine O. Menias, MD, Nancy A. Hammond, MD, Vahid Yaghmai, MD, Guang-Yu Yang, MD, Frank H. Miller; md; Uncommon Intraluminal Tumors of the Gallbladder and Biliary tract: Spectrum of Imaging Appearances; RadioGraphics 2019; 39: 388-412
Jae Hoon Lim, MD, Myung-Han Kim , MD, Tae Kyoung Kim, MD, Moon-Gyu Lee, MD, Sang Soo Lee, MD, Jin Wook Lee, MD, Kyu Taek Lee, MD, Jong Kyun Lee, MD, Hyo...