Aim is to understand the basic concepts of MR Spectroscopy and it's importance in improving the diagnostic accuracy of pediatric brain lesions. Fig. 1
MR spectroscopy is a non-invasive technique used to measure the concentrations of different low-molecular weight chemicals within the body. Spectroscopy focuses on carbon-bound protons in the range of 1–5 ppm chemical shift scale and can depict metabolites that are present at high enough concentrations. 1,2 Chemical shift effect MR Spectroscopy is based on chemical shift effect. The chemical shift is the position on the δ scale (in ppm) where the peak occurs. The frequency of precession of a...
Findings and procedure details
Steps in MRS acquisition Fig. 4 TYPES OF MRS Single voxel •A small volume is selected (1x1x1 cm) •Voxel positioning is critical- Voxel must be positioned away from sources of susceptibility artifacts and lipids •Excellent shim and spectral resolution •The main limitation of this technique is restricted anatomic coverage ie, the assessment of only one single area during normal acquisition Multi voxel (MVS) •Larger volume is selected which yields spectra from multiple voxels simultaneously...
Summary of pediatric disorders that can be picked upby MRS Fig. 28 MR Spectroscopy is a non invasive imaging modality to study the presence and concentration of metabolites in a given area of interest.MRS helps in the early diagnosisof certainpediatricconditionsand thereby facilitates early initiation of treatment.
Personal information and conflict of interest
Dr.Athul.D; Chennai, TAMIL NADU/IN - nothing to disclose K. Gopinathan; Chennai/IN - nothing to disclose P. D. J. Devimeenal; Chennai/IN - nothing to disclose D. K. Geetha; Chennai/IN - nothing to disclose D. R. Rajakumaran; Chennai/IN - nothing to disclose
1)Gülin Öz et al. Clinical Proton MR Spectroscopy in Central Nervous System Disorders 2) Girard N et al. Assessment of normal fetal brain maturation in utero by proton magnetic resonance spectroscopy. 3)Osborn’s text book of brain imaging, anatomy & pathology. 4) Stephan Ulmer et al. Basic Principles and Clinical Applications of Magnetic Resonance Spectroscopy in Neuroradiology 5) Joshua M. Tognarelli et al. Magnetic Resonance Spectroscopy: Principles and Techniques: Lessons for Clinicians