Aims and objectives
Human bocavirus (HBoV) is a newly identified pathogen that can cause
upper and lower respiratory tract infections.
In a recent prospective study,
HBoV was the fourth themost common pathogen in hospitalized children with respiratory tract diseases.
However,
HBoV has been rarely detected in adults.
Therefore,
the purpose of this study was to describe the clinical and radiologiccharacteristics of HBoV infections in adult using a large population cohort of a tertiaryhospital.
Methods and materials
Data collection
This retrospective cohort study was conducted with the approval of the institutional review board at the Asan Medical Center,
and the requirement for informed consent was waived.
We searched the hospital database to identify all patients who had laboratory-confirmed HBoV infections between January 2010 and December 2017.
Patient characteristics including demographics,
smoking history,
underlying chronic disease,
body mass index,
immune status,
and features of HBoV infection,
which included seasonality,
type of infection (community acquired or nosocomial),
and presence of coinfection were thoroughly reviewed....
Results
Patient characteristics and seasonality of HBoV infection
Of the 185 patients with HBoV infections,
75 (40.5%) had upper respiratory infection alone and 110(64.3%) had pneumonia.
Patient characteristics are shown in Table 1.
Coinfections were detected in 88 patients (47.6%).
The most frequent respiratory viral co-pathogens were rhinovirus (n=8,
10.7%) in URIand adenovirus (n=5,
4.6%) and influenza A or B virus (n=5,
4.6%) in pneumonia.
Infections were predominantly noted between February and June(Fig. 1),
with a peak incidence in April(15.7%).
Clinical outcomes of HBoV infection
All-cause...
Conclusion
HBoV infection can cause respiratory infections in adults and is associated
with a high incidence of pneumonia,
especially in nosocomial and older patients.Although neutropenia and lymphopeniawere not significant risk factors for pneumonia in this study.
The overall mortality rate of HBoV infection at 30 days(7.6%) was similarwith those for other respiratory viral infections,
such as human metapneumovirus and RSV,
inadult patients (7-8%).Whereas HBoV infections in children showed a less severe disease course than RSV infections.
Thepredominant CT findings of HBoV pneumonia were bilateral consolidation and...
Personal information
Soo Hyun KIM,
MD.
Redsident,
Department of Radiology,Asan Medical Center,University of Ulsan College of Medicine,
Seoul,
Republic of Korea.
Phone: +821085799389
e-mail :
[email protected]
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