Learning objectives
Retrospective analysis of 16 pancreatic neuroendocrine tumor (pNET) cases in our institution; and to reviewthe literature seeking for the radiologyc characteristics of pNETs,
the role of sonography,
CT,
and MRI in their diagnosis and their prognostic factors.
Background
Pancreatic neuroendocrine tumors (pNETs) are rare neoplasms that arise in the endocrine tissues of the pancreas.
They have an incidence of ≤1 case per 100,000 individuals per year and account for 1 to 2 percent of all pancreatic tumors.
Pancreatic NETs represent less than 3 percent of primary pancreatic neoplasms.
Incidence rates have been increasing and elsewhere over the last two decades,
but it is likely that this is mainly related to increased detection of asymptomatic disease on cross-sectional imaging and endoscopy done for other...
Findings and procedure details
We conducted a retrospective search of 16 consecutive patients with pancreatic neuroendocrine tumor (pNET).
Information about 13 cases of pancreatic NET patients was obtained from the pathology databases of theHospital Universitario de Móstoles (Madrid,
Spain) for the period between 2011 and 2018.
The other 3 cases are patients with suggestive image findings of pNET but not confirmed by anatomy pathology yet.
The following clinical parameters were assessed from the medical records: age,
gender,
medical history,
the presence of tumor-related symptoms (i.e.,
abdominal pain),
the presence...
Conclusion
Pancreatic NETs are rare neoplasms and they can present a diagnostic challenge,
both clinically and radiologically.
The majority are nonsyndromic.
Insulinoma,
gastrinoma,
and glucagonoma are the most common syndromic pNETs.
While most pNETs are sporadic,
they can also be associated with genetic syndromes.
CT isthe primary imaging modality and plays an important role in the diagnosis and staging of both syndromic and nonsyndromic pNETs.
Most of them are well-differentiated,
circumscribed,
and hypervascular at CT and MR imaging.
Smaller tumors tend to be more homogeneous than...
Personal information
"Hospital Universitario de Móstoles":
-Jacob Sánchez Dalmau: 2nd-year-residentradiology doctor.
[email protected].
-Marta Babarro Peleteiro: 3rd-year-resident radiology doctor.
[email protected]
-Patricia Gómez Iglesias: pathological anatomy doctor.
-María Luisa Rodriguez Rodil:radiology doctor .
References
1.
Horton,
K.
M.,
Hruban,
R.
H.,
Yeo,
C.,
& Fishman,
E.
K.
(2006).
Multi–detector row CT of pancreatic islet cell tumors.Radiographics,26(2),
453-464.
2.
P Buetow,
P.
C.,
Parrino,
T.
V.,
Buck,
J.
L.,
Pantongrag-Brown,
L.,
Ros,
P.
R.,
Dachman,
A.
H.,
& Cruess,
D.
F.
(1995).
Islet cell tumors of the pancreas: pathologic-imaging correlation among size,
necrosis and cysts,
calcification,
malignant behavior,
and functional status.AJR.
American journal of roentgenology,165(5),
1175-1179
3.
Lewis,
R.
B.,
Lattin Jr,
Maj,
G.
E.,
& Paal,
E.
(2010).
Pancreatic...