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ECR 2019 / C-2107
Certificate of Merit
Ultrasmall Superparamagnetic Iron Oxide Enhanced Peripheral MR Lymphangiography – An Effective Method to Reduce Venous Contrast Contamination through Selective Blood Pool Suppression
Congress: ECR 2019
Poster No.: C-2107
Type: Educational Exhibit
Keywords: Oedema, Imaging sequences, Contrast agent-intravenous, MR-Angiography, MR, Lymphography, Veins / Vena cava, Contrast agents, Cardiovascular system
Authors: O. Kolokythas1, N. Briller1, J. Revels1, S. Kim2, P. Neligan1, L. Mitsumori3, A. Gutzeit4, N. Lalwani5, J. H. Maki6; 1Seattle, WA/US, 2New York, NY/US, 3Honolulu, HI/US, 4Luzern/CH, 5Winston Salem, NC/US, 6Denver, CO/US


  1. Landry R, Jacobs PM, Davis R, et al. Pharmacokinetic study of ferumoxytol: A new iron replacement therapy in normal subjects and hemodialysis patients. Am J Nephrol 2005;25:400–10.
  2. Adkinson NF, Strauss WE, Macdougall IC, Bernard KE, Auerbach M, Kaper RF, Chertow GM, Krop JS. Comparative safety of intravenous ferumoxytol versus ferric carboxymaltose in iron deficiency anemia: A randomized trial. Am J Hematol. 2018;93(5):683.
  3. Damstra RJ, Voesten HG, van Schelven WD, van der Lei B. Lymphatic venous anastomosis (LVA) for treatment of secondary arm lymphedema. a prospective study of 11 LVA procedures in 10 patients with breast cancer related lymphedema and a critical review of the literature. Breast Cancer Res Treat 2009;113(2):199–206.
  4. Toth GB, Varallyay CG, Horvath A, et al. Current and potential imaging applications of ferumoxytol for magnetic resonance imaging. Kidney Int 2017;92(1):47–66.
  5. Finn JP, Nguyen KL, Hu P. Ferumoxytol vs. gadolinium agents for contrast-enhanced MRI: thoughts on evolving indications, risks, and benefits. J Magn Reson Imaging 2017 Sep;46(3):919-923.
  6. Mitsumori LM, Mcdonald ES, Wilson GJ, Neligan PC, MinoshimaS, Maki JH. MR lymphangiography: How I do it. J MagnResonImaging. 2015;42(6):1465-77
  7. Maki JH, Neligan PC, Briller N, Mitsumori LM, Wilson GJ. Dark blood magnetic resonance lymphangiography using dual-agent relaxivity contrast (DARC-MRL): a novel method combining gadolinium and iron contrast agents. Curr Probl Diagn Radiol 2016;45(3):174–179.

  8. Neligan PC, Kung TA, Maki JH. MR lymphangiography in the treatment of lymphedema. J SurgOncol. 2017;115(1):18-22.
  9. Ripley B, Wilson GJ, Lalwani N, Briller N, Neligan PC, Maki JH. Initial Clinical Experience with Dual-Agent Relaxation Contrast for Isolated Lymphatic Channel Mapping, Radiology. 2018 Feb;286(2):705-714 
  10. Bae JS, YooRE, Choi SH, Park SO, Chang H, Suh M, Cheon GJ. Evaluation of lymphedema in upper extremities by MR lymphangiography: Comparison with lymphoscintigraphy. MagnResonImaging. 2018;49:63-70.
  11. O’Donnell TF, Rasmussen JC, Sevick-Muraca EM. New Diagnostic Modalities in the Evaluation of Lymphedema. Journal of vascular surgery Venous and lymphatic disorders. 2017;5(2):261-273. 
  12. Sty JR, Boedecker RA, Scanlon GT, Babbitt DP. Radionuclide "dermal backflow" in lymphatic obstruction. J NuclMed. 1979;20(8):905-6.
  13. Mihara M, Hayashi Y, Hara H, et al. High-accuracy diagnosis and regional classification of lymphedema using indocyanine green fluorescent lymphography after gynecologic cancer treatment. Ann PlastSurg. 2014;72(2):204-8.
  14. Witte CL, Witte MH, Unger EC, et al. Advances in imaging of lymph flow disorders. Radiographics. 2000;20(6):1697-719.
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