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ECR 2019 / C-2697
Dynamic PET Perfusion Imaging (DPPI) to Characterize Thoracic Tumors: A Phase I Assessment of Ultra-fast Digital PET as an Imaging Biomarker
Congress: ECR 2019
Poster No.: C-2697
Type: Scientific Exhibit
Keywords: Molecular imaging, Nuclear medicine, Oncology, PET-CT, Cancer, Biological effects
Authors: M. V. Knopp1, E. D. Miller2, K. Binzel1, T. M. Williams1, P. Kneuertz2, M. Welliver2, M. I. Knopp1, C. L. Wright1, J. Zhang1; 1Columbus, OH/US, 2Columbus/US



Dynamic PET Perfusion Imaging can be readily obtain using current and next-gen digital PET systems. The image quality was consistenly diagnostic, however required optimzed reconstruction adjusting for the count sparsity of very short frame times.


Fig.2 presents a coronal view of a DPPI at 1min/frame of patient with an esophageal tumor, Fig.3 using 15 s/ frame both over the first 15 min. Fig. 4 at 9 s/frame over 4 minutes and Fig. 5 at 1 s/frame over 1 min.


Fig. 6 Present the baseline and follow up whole body scans and Fig. 7 presents the dynamic uptake time curves of the four different resolutions at baseline and follow up.


Frame rates of 10 sec/fr led to high quality uptake time curves of the well delineated tumors enabled by a count density adaptive reconstruction approach.


The first 2 min duration of the dynamic series were found to be the most relevant for the perfusion assessment. Uptake time curves were found to be highly analogous to characteristic findings in DCE-MRI.



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