|ECR 2019 / C-1461|
|Tolerability of endobiliary photodynamic therapy in non-surgical Klatskin tumour patients|
Methods and materials
The intraprocedural adverse events of 159 EPDT’s performed in 62 biopsy confirmed non-surgical Klatskin tumor patients in a ten-year period were studied. The endobiliary light delivery was fulfilled though the previously inserted percutaneous transhepatic biliary drainage channels by mean of a 600 µm in diameter optical fiber with a 2 to 6 cm diffuser tip after prior 2 to 5 hours i.v. injection of chlorin photosensitizers ( Fig. 5 ). Intraprocedural adverse events included pain, hemodynamic disorders, shaking chill, nausea and vomiting. They were distributed into 3 grades: 1 – no or requiring medication only; 2 – requiring fluence rate reduction; 3 – requiring procedure cessation ( Fig. 6 ). Their dependence on total dose (range 64.6-3240 J), fluence rate (range 19,1 - 288 mW/cm2), power density (range 14,5-206,3 J/cm2), diffuser tip length (2,3,5,6 cm) , number of channels (range 1-4), photoexposure time (range 3-240 min), photosensitizing drug (Photolon, Fotoditazin, Radahlorin) and its dosage (0.6-2.0 mg/kg) was analyzed ( Fig. 5 ).
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Percutaneous multiple metallic stent placement for bilateral drainage in malignant hilar biliary obstruction.
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