|ECR 2019 / C-0525|
|Influence of ROI placement: different ADC metrics on diagnostic accuracy of DWI in NME breast tumours|
Methods and materials
In this IRB-approved single-institution study and retrospective data analysis 95 patients, who underwent multiparametric MRI with DCE and DWI and were diagnosed with a suspicious NME breast lesion (BI-RADS 4/5) were included in this study.
Two readers independently assessed DWI and DCE in two separate randomized readings with a wash-out period of at least 3 weeks.
For DWI readers recorded ADC mean values using:
a) Whole tumor (Wtu) ROI, b) Darkest part (Dptu) tumor 10 mm ROI and c) point tumor (Ptu) 3 mm ROI.
NME lesions were classified as a benign (>1.3 x10-3 mm2/s) or malignant (1.3 x 10-3 mm2/s). Histopathology was the standard of reference.
ROC curves were plotted and the area under the curve (AUC) was determined.
The concordance correlation coefficient (CCC) was performed to examine agreement on continuous measures (MRI features) obtained by the two independent readers
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