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ECR 2019 / C-1620
Usefulness of fusion MRI in ADC analysis after neoadjuvant chemotherapy in patients with breast cancer
Congress: ECR 2019
Poster No.: C-1620
Type: Scientific Exhibit
Keywords: Breast, MR-Diffusion/Perfusion, MR, MR-Functional imaging, Contrast agent-intravenous, Chemotherapy, Cancer, Neoplasia
Authors: N. Belleggia1, C. De Cataldo1, E. Di Cesare1, C. Masciocchi1, A. Di Sibio2; 1L'Aquila/IT, 2L'Aquila, ITALY/IT


Breast volumes: 2 patients showed no response to chemotherapy. 38  patients showed a  response to chemotherapy  and were divided  into three responders groups: complete responders, responders  with  reduction of tumor lesions >80%  and responders with reduction of tumor lesions < 80%.

At 1.5 tesla scanner 28 patients were evaluated :  9 patients had complete regression of breast cancer, 7 patients had a volume reduction of breast lesion  > 80% and  12 patients had a volume reduction of breast tumor <80% .

At 3Tesla scanner 10 patients were evaluated:  4 patients showed a  complete regression of breast cancer , 3 patients had a volume  reduction  >80% and  3 patients had a volume reduction < 80%.

Using the non parametric test Wilcoxon test  to analyze the volume reduction of breast lesions examined at 1.5 tesla and at 3 Tesla we obtained  a statistically significant volume reduction( P value <0.0001) , even at 3tesla with a very small  patients sample size (Fig 3 -  Fig4 – Fig .5).

We  analyzed ADC values by Wilcoxon test and we noticed that patients with complete response showed lower ADC values (mean=0,590 ± 0,16 x 10-3 mm2/s). Post NACT ADC values of responder patients >80% were significantly higher than pre- treatment values (mean=1,23±0,2 vs mean=0,880±0,28) (p=0,02); in patients with decrease of tumor volume< 80% there was no statistically significant difference between pre and post treatment ADC values ( mean= 0,85±0,15 vs mean=0,93±0,22) (p=0,778) (Fig. 6 )


The pre and post treatment ADC values obtained from the 3T sample using fusion technique,  didn’t shown a statistically significant difference (p<0.625) , probably due to the small sample size, although ADC values tended to increase after NACT.( Fig.7- Fig.8)



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