Aims and objectives
There are different phenotypic differences between cancers of the same organ which can only be visualized using radiographic imaging.
[1,
2] Breast carcinoma is the most common cancer with a reported prevalence of 1 in 9 women in Pakistan.
[3] Early and accurate detection of breast cancer and delineation of its histologic subtype is crucial to instituting appropriate treatment.
In the era of personalized medicine,
tailoring therapies to specific molecular and genomic profiles of cancers is essential for improving outcomes and making accurate prognostic inferences....
Methods and materials
A retrospective study was performed at the Dow Institute of Radiology and all women aged 18 years or older were eligible for inclusion.
Data was retrieved using the hospital’s electronic medical record (EMR) system.
All patients who had histopathological confirmation of infiltrative ductal breast carcinoma and who subsequently underwent CT chest for staging were included in the study.
All patients who had either tumour recurrence or previous surgery related to the breast were excluded from the study.
Histopathological and immunohistochemical data were recorded using a...
Results
A total of 32 women with a median age of 48 (interquartile range: 39–55) years were included in the study.
Histologic grading of infiltrating ductal carcinoma was made in accordance with modified Bloom and Richardson classification.
Seven (21.9%),
18 (56.2%) and 7 (21.9%) cancers were well,
moderately and poorly differentiated respectively.
The demographic,
histopathological and immunohistochemical features of subjects included in the study are mentioned intable2.
Characteristics
n (%)
Women
32 (100%)
Median age (IQR)
48 (39–55) years
Histologic grade of cancer
Well-differentiated
7 (21.9%)...
Conclusion
The results of this study suggest that CT texture parameters may be used as imaging biomarkers of histological and immunohistochemical features in infiltrating ductal carcinoma of the breast.
Further studies utilizing different software and with larger sample sizes are required to further validate and standardize these results for routine clinical practice.
Personal information
DR MUHAMMAD AWAIS
ASSISTANT PROFESSOR
DOW INSTITUTE OF RADIOLOGY
KARACHI,
PAKISTAN
[email protected]
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