To understand the classification of crystal deposition diseases. To learn the pathophysiology of this disorder. To understand the clinical manifestations of this disorder. To learn the radiographic distribution and appearance using example radiographs and the target approach to radiographic diagnosis. To understand the complications of CPPD crystal deposition disease. To differentiate CPPD crystal deposition disease from those disorders that can be confused with it,
History: Intra-articular CPPD crystals were initially described by McCarty,
et al in 1961 and 1962. 1,
2 Zitnan and Sitaj had previously described the findings of CPPD crystal-deposition disease in 1958,
calling it “chondrocalcinosis polyarticularis”. 3
Imaging findings OR Procedure Details
Differential Considerations Osteoarthritis: Pyrophosphate arthropathy most commonly presents with imaging characteristics similar to OA with a specific distribution. Subchondral cysts in CPPD CDD are generally larger. OA in an atypical location (i.e.
consider CPPD—even in the absence of chondrocalcinosis. Septic arthritis and gout: Clinically,
this can be a difficult differentiation from pseudogout attack. Patients can present with fever and...
References: McCarty DJ,
Identification of urate crystals in gouty synovial fluid.
Ann Intern Med 1961; 54:452-460. McCarty DJ,
The significance of calcium pyrophosphate crystals in the synovial fluid of arthritis patients: the “pseudogout” syndrome.
Ann Intern Med 1962; 56:711-737. Zitnan D,
Clinical and radiological study.
Ann Rheum Dis 1963; 9:397-406. Steinbach LS,
Calcium pyrophosphate dihydrate...