Learning objectives
1.
To present the epidemiology,
pathogenesis,
clinical manifestations and differential diagnosis of mammary-type myofibroblastoma,
2.
To show the different locations of mammary-type myofibroblastoma with its multi-modality imaging including radiography,
ultrasound,
CT,
MR and PET/CT.
Background
See attched slide
BACKGROUND
Myofibroblastoma was first described by Wargotz et al.
in 1987 as a benign tumor of the breast generally seen in older men.
Mammary-type myofibroblastoma is a rare tumor resembling its mammary counterpart.
It is accepted that this tumor arises from accessory breast tissue typically occurring along the embryonic milk-line from the axilla to the medial groin.
Almost half of cases are located in the pelvis or inguinal region.
About 25% of mammary-type myofibroblastoma occur outside the expected embryonic milk-line,
at locations...
Imaging findings OR Procedure Details
See attached slides.
IMAGING FINDINGS
The exhibit presents the spectrum of features of mammary-type myofibroblastoma on ultrasound,
CT,
MR and PET/CT imaging and discusses their differential diagnosis based on early or advanced stages of the lesion.
The exhibit also reviews the different sites of mammary-type myofibroblastoma with the pictorial essay of pelvic,
ischio-rectal,
back,
inguinal,
thoracic wall,
breast and lower extremity involvement.
An instance of recurrent tumor is also discussed and illustrated.
GENERALITIES
Mammary-type myofibroblastoma (MTMF) is a benign mesenchymal tumor initially described as breast...
Conclusion
The viewers will be familiar with mammary-type myofibroblastoma,
its histopathology,
epidemiology,
imaging features,
sites of involvement,
and treatment.
The take-home points for mammary-type myofibroblastoma are:
1.
Slow growing tumor with variable lipomatous component,
and symptomatic at large size with mass effect,
2.
Male gender and fifth decade of life predominance,
3.
Sites: inguina,
lower extremity and trunk
4.
Well-circumscribed,
"rubbery-to-gelatinous" consistency,
not encapsulated with absence of cystic degeneration,
necrosis,
or hemorrhage,
5.
Diagnosis by immunohistochemistry with positivity to CD34 and desmin,
6.
Complete surgical resection...
References
1.Kuyumcu G,
Rubin BP,
Winalski C.
Imaging features of mammary-type myofibroblastoma of soft tissue: a case series with literature review.
Skeletal Radiol.
2017 Sep;46(9):1283-91.
2.Howitt BE,
Fletcher CD.
Mammary-type Myofibroblastoma: Clinicopathologic Characterization in a Series of 143 Cases.
Am J Surg Pathol.
2016 Mar;40(3):361-7
3.McMenamin ME,
Fletcher CD.
Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma.
Am J Surg Pathol.
2001 Aug;25(8):1022-9.