Keywords:
Endocrine disorders, Diagnostic procedure, Computer Applications-General, MR, Cardiac, Metabolic disorders, Tissue characterisation
Authors:
C. Roux1, N. Kachenoura1, P. Kamenicky2, L. Hajji-Besson1, M. J. Graves3, E. Mousseaux4, P. Chanson2, A. Redheuil4; 1Paris/FR, 2Krêmelin-Bicêtre/FR, 3Cambridge/UK, 4Paris Cedex 15/FR
Results
All Patients’ characteristics at baseline and after treatment are summarized in table 1.
Ten patients aged 36±15 years (9 women,
1 man) were included and matched to ten controls on age (36±9 years),
sex and heart rate. BMI of patients and controls were not significantly different (p=0.080),
but systolic and diastolic pressures were increased in patient which is expected in this disease (120±14 vs.
100±13,
p=0.002 and 75±10 vs.
73±34,
p=0.023 respectively).
Morphological and functional parameters,
T1,
λ before and after contrast are summarized in Table 2.
No patient nor volunteer had late gadolinium enhancement.
Before cortisol normalization,
native myocardial T1 was increased in CD patients (1031±106 ms to 959±45 ms,
p=0.049).
T1 values 15 minutes after enhancement were not significantly increased.
After treatment,
native T1 decreased markedly (830±78 ms vs.
1031±106,
p=0.004) becoming even lower than controls (p=0.009).
These findings favor the hypothesis of differential resolution of steatosis4 caused by metabolic syndrome5 and edema induced by CD.
This hypothesis may be further enhanced by the strong inverse correlation between native T1 before treatment and FLU24H (Figure 2).
Before treatment,
left ventricular ejection fraction was decreased in patients (p<0.028) and left ventricular mass was increased (p=0.076).
After treatment,
both parameters tended to correct without reaching statistical significance (p=0.191 and p=0.194,
respectively).