Keywords:
Cardiac, MR, Diagnostic procedure, Haematologic diseases
Authors:
C. Tudisca1, A. Meloni2, E. Chiodi3, R. Rosso4, A. Carollo5, M. Midiri1, A. Pepe2; 1Palermo/IT, 2Pisa/IT, 3Ferrara/IT, 4Catania/IT, 5Trapani/IT
Results
At baseline the mean age of the patients was 29.5±9.0 years,
222 were males and the mean serum ferritin level were 1742.49 ± 1592.72 ng/l.
The mean follow-up time was 58 ± 18 months.
After the first CMR scan only the 37.8% of the patients did not change the chelation regimen or the frequency/dosage of the chelators.
We recorded 19 episodes of heart failure,
diagnosed by clinicians based on symptoms,
signs and instrumental findings (electrocardiogram,
echocardiography and CMR) according to the current guidelines.
Male sex,
heart iron,
ventricular dysfunction,
ventricular dilation,
atrial dilation,
and myocardial fibrosis were significant univariate prognosticators.
In the multivariate analysis the independent predictive factors were an homogeneous pattern of myocardial iron overload (compared to no MIO),
myocardial fibrosis and ventricular dysfunction (Table 1).
Figure 1 shows the Kaplan–Meier survival curves for the prognosticators.
Arrhythmias occurred in 19 patients and all were supraventicular hyperhyperkinetic.
Male sex,
atrial dilatation and ventricular dysfunction were significant univariate prognosticators.
In the multivariate analysis the independent predictive factors were male sex and atrial dilation (Table 2).
Figure 2 shows the Kaplan–Meier survival curves for the prognosticators.