Purpose
Left ventricular mass (LVM) is an important independent risk factor for cardiovascular (CV) morbidity and mortality.
In the ROMICAT (rule out myocardial infarction using computer assisted tomography) study,
increased LVM and LVMi measured by MDCT were associated with a greater degree of CT-detected coronary plaque burden.
Abnormal LVM can be detected in young adults with other cardiovascular risk factors (e.g.
obesity and hypertension),
long before cardiovascular morbidity.
If subclinical CAD and abnormal LVM can be detected in young adulthood long before CV events occur,
the...
Methods and Materials
We retrospectively enrolled 490 consecutive individuals (383 males; mean age,
35.2 ± 4.4 years) who underwent cardiac CT.
CV risk factors for the entire study population were obtained through review of medical records at the time of cardiac CT examinations.
10-year CHD risk based on the Framingham risk score (FRS) was calculated for each patient.
Image acquisition was performed using a dual source 128-slice CT (Somatom Definition FLASH; Siemens Healthcare,
Forchheim,
Germany).
First,
all patients underwent non-enhanced imaging to calculate the coronary artery calcium (CAC)...
Results
Clinical characteristics of the study population are described in Table 1.
Table 1 Clinical characteristics of the subjects (n = 490)
Characteristics
Values (%)
Age,
years
35.2 ± 4.4
Male / Female
383 / 107
Symptom
Typical chest pain
6 (1.2%)
Atypical chest pain
35 (7.1%)
Non-anginal pain
180 (36.7%)
Asymptomatic
269 (54.9%)
Pretest probability
Intermediates
55 (11.2%)
Low
165 (33.7%)
Very low
270 (55.1%)
HR,
bpm
61.6 ± 11.6
Agatston calcium score
1.8 ± 19.5
Zero
462 (94.3%)
1-10
16 (3.3%)
10-100
11 (2.2%)...
Conclusion
LVM and LVMi were higher in young patients with CT-detected CAD than those without.
In a multivariate analysis,
LVM and LVMI measured by cardiac CT were independent predictors of CAD.
References
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