Keywords:
Cardiac, Echocardiography, CT-Angiography, MR, Contrast agent-intravenous, Diagnostic procedure, Congenital, Tissue characterisation, Image verification
Authors:
V. Barskiy, V. Sinitsyn, L. A. Yurpolskaya, E. Basargina, Y. Shmeleva, I. Filinov, A. Sugak, I. Silnova, M. umarova; Moscow/RU
Purpose
Left ventricular non-compacted cardiomyopathy (LVNC) is a rare disease.
It is morphologically characterized by increased left ventricular (LV) trabeculation and deep intertrabecular recesses communicating with the LV cavity.
The disease usually has genetic or inherited pattern.
But clinical manifestations and severity of clinical course often do not correlate with the severity of morphological changes.
It is well known that prominent LV trabeculations may be found in up to 20-30% of patients without LVNC (in athletes,
patients with LV overload due to valvular or congenital heart diseases,
hypertrophic or dilative cardiomyopathy).
Diagnosis of LVNC is on clinical and imaging manifestations of the disease.
Cardiac imaging modalities (echocardiography,
cardiac MRI,
in some cases – low-dose CT) play an important role in diagnosis of LVNC.
Some thresholds based on the ratio of the noncompacted to the compacted myocardial tissue have been proposed for diagnosis of LVNC.
For cardiac MRI the mostly used diagnostic criteria of non-compact myocardium is the ratio 2.3 or more of non-compact layer to compact in diastole (in presence of two-layered structure with compacted-noncompacted layers – Petersen et al.,
2005) in one of the three long projections or percentage of LV trabeculated mass above 20% (Jacquier et al.
2010).
But all these criteria are based on studies with rather small number of patients (from 7 to 62) and therefore they still seem to controversial.